Epigenetics & Nuclear Signaling Antibodies 5
Anti-MGMT Antibody (CAB11151)
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- SKU:
- CAB11151
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-MGMT Antibody |
| Antibody SKU: | CAB11151 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human MGMT |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, MCF7, Jurkat |
| Immunogen: | A synthesized peptide derived from human MGMT |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4255 |
| Uniprot: | P16455 |
| Cellular Location: | |
| Calculated MW: | 22kDa |
| Observed MW: | 22KDa |
 | Western blot - MGMT Rabbit mAb (CAB11151) |
| Synonyms: | |
| Background: | Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015] |
| UniProt Protein Function: | MGMT: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family. |
| UniProt Protein Details: | Protein type:EC 2.1.1.63; Methyltransferase; Nuclear receptor co-regulator; DNA repair, damage; Apoptosis Chromosomal Location of Human Ortholog: 10q26 Cellular Component: nucleoplasm; membrane; nucleus Molecular Function:methyltransferase activity; DNA binding; methylated-DNA-[protein]-cysteine S-methyltransferase activity; damaged DNA binding; calcium ion binding; DNA-methyltransferase activity Biological Process: response to drug; response to ethanol; positive regulation of DNA repair; DNA dealkylation; response to folic acid; response to toxin; DNA methylation; regulation of caspase activity; DNA repair; DNA ligation |
| UniProt Code: | P16455 |
| NCBI GenInfo Identifier: | 127069 |
| NCBI Gene ID: | 4255 |
| NCBI Accession: | P16455.1 |
| UniProt Secondary Accession: | P16455,Q5VY78, |
| UniProt Related Accession: | P16455 |
| Molecular Weight: | 21,646 Da |
| NCBI Full Name: | Methylated-DNA--protein-cysteine methyltransferase |
| NCBI Synonym Full Names: | O-6-methylguanine-DNA methyltransferase |
| NCBI Official Symbol: | MGMT |
| NCBI Protein Information: | methylated-DNA--protein-cysteine methyltransferase; methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase; O6-methylguanine-DNA methyltransferase; 6-O-methylguanine-DNA methyltransferase |
| UniProt Protein Name: | Methylated-DNA--protein-cysteine methyltransferase |
| UniProt Synonym Protein Names: | 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase |
| Protein Family: | Probable methylated-DNA--protein-cysteine methyltransferase |
| UniProt Gene Name: | MGMT |
| UniProt Entry Name: | MGMT_HUMAN |
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