Cell Biology Antibodies 3
Anti-MGAT4B Antibody (CAB12810)
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- SKU:
- CAB12810
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MGAT4B Antibody |
| Antibody SKU: | CAB12810 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 409-548 of human MGAT4B (NP_055090.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-549 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 409-548 of human MGAT4B (NP_055090.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TYQH FTLE KAYL REDF FWAF TPAA GDFI RFRF FQPL RLER FFFR SGNI EHPE DKLF NTSV EVLP FDNP QSDK EALQ EGRT ATLR YPRS PDGY LQIG SFYK GVAE GEVD PAFG PLEA LRLS IQTD SPVW VILS EIFL KKAD |
| Gene ID: | 11282 |
| Uniprot: | Q9UQ53 |
| Cellular Location: | Golgi apparatus membrane, Single-pass type II membrane protein |
| Calculated MW: | 63kDa/64kDa |
| Observed MW: | 63kDa |
| Synonyms: | MGAT4B, GNT-IV, GNT-IVB, alpha-1 |
| Background: | This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1, 4 linkage to the Man-alpha-1, 3-Man-beta-1, 4-GlcNAc arm of R-Man-alpha-1, 6(GlcNAc-beta-1, 2-Man-alpha-1, 3)Man-beta-1, 4-GlcNAc-beta-1, 4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. |
| UniProt Protein Function: | Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis. |
| NCBI Summary: | This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UQ53 |
| NCBI GenInfo Identifier: | 74735195 |
| NCBI Gene ID: | 11282 |
| NCBI Accession: | Q9UQ53.1 |
| UniProt Secondary Accession: | Q9UQ53,Q86TF1, Q96GH4, Q9NSK6, A8MPR0, |
| UniProt Related Accession: | Q9UQ53 |
| Molecular Weight: | 64,845 Da |
| NCBI Full Name: | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B |
| NCBI Synonym Full Names: | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B |
| NCBI Official Symbol: | MGAT4B |
| NCBI Official Synonym Symbols: | GNT-IV; GNT-IVB |
| NCBI Protein Information: | alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B |
| UniProt Protein Name: | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B |
| UniProt Synonym Protein Names: | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; GlcNAc-T IVb; GnT-IVb; N-acetylglucosaminyltransferase IVb; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb |
| Protein Family: | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
| UniProt Gene Name: | MGAT4B |
| UniProt Entry Name: | MGT4B_HUMAN |
 | Western blot analysis of extracts of A-549 cells, using MGAT4B antibody (CAB12810) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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