Anti-MEKK3 Antibody (CAB3695)

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SKU:
CAB3695
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MAPKKK3
Synonyms:
MEKK3
Research Area:
Cell Biology

Description

Product Name:MEKK3 Rabbit mAb
Product Code:CAB3695
Size:20uL, 50uL, 100uL
Synonyms:MAPKKK3, MEKK3
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human MEKK3
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, NIH/3T3, Jurkat, SH-SY5Y, Mouse spleen
Immunogen:A synthesized peptide derived from human MEKK3
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4215
Uniprot:Q99759
Calculated MW:71kDa
Observed MW:78kDa
UniProt Protein Function:MEKK3: a protein kinase of the STE11 family. Phosphorylated and activated by MLK3 and TAK1. Phosphorylates and activates MEK5.
UniProt Protein Details:

Protein type:Protein kinase, STE; Kinase, protein; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: intracellular; cytosol

Molecular Function:MAP kinase kinase activity; protein binding; MAP kinase kinase kinase activity; metal ion binding; ATP binding; protein kinase activity

Biological Process: blood vessel development; positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of MAPKK activity; activation of MAPK activity; protein amino acid autophosphorylation; MAPKKK cascade

NCBI Summary:This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
UniProt Code:Q99759
NCBI GenInfo Identifier:160332306
NCBI Gene ID:4215
NCBI Accession:Q99759.2
UniProt Secondary Accession:Q99759,Q5BKZ6, Q8N3I9, B2RCW2, D3DU15,
UniProt Related Accession:Q99759
Molecular Weight:74,089 Da
NCBI Full Name:Mitogen-activated protein kinase kinase kinase 3
NCBI Synonym Full Names:mitogen-activated protein kinase kinase kinase 3
NCBI Official Symbol:MAP3K3  
NCBI Official Synonym Symbols:MEKK3; MAPKKK3  
NCBI Protein Information:mitogen-activated protein kinase kinase kinase 3; MEKK 3; MEK kinase 3; MAP/ERK kinase kinase 3; MAPK/ERK kinase kinase 3
UniProt Protein Name:Mitogen-activated protein kinase kinase kinase 3
UniProt Synonym Protein Names:MAPK/ERK kinase kinase 3; MEK kinase 3; MEKK 3
UniProt Gene Name:MAP3K3  
UniProt Entry Name:M3K3_HUMAN
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