Anti-MDM2 Antibody

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SKU:
STPA00083
Antibody Type:
Polyclonal
Applications:
WB
Applications:
IHC
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
  • Immunohistochemistry analysis using Rabbit Anti-MDM2 Polyclonal Antibody (STPA00083). Tissue: Stomach Cancer. Species: Human. Fixation: Formalin Fixed Paraffin-Embedded. Primary Antibody: Rabbit Anti-MDM2 Polyclonal Antibody (STPA00083) at 1:50 for 30 min at RT. Counterstain: Hematoxylin. Magnification: 10X. HRP-DAB Detection.
  • Western blot analysis of Mouse, Rat Brain showing detection of ~40 kDa MDM2 protein using Rabbit Anti-MDM2 Polyclonal Antibody (STPA00083). Lane 1: Molecular Weight Ladder (MW). Lane 2: Mouse Brain. Lane 3: Rat Brain. Load: 15 µg. Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-MDM2 Polyclonal Antibody (STPA00083) at 1:1000 for 2 hours at RT. Secondary Antibody: Goat Anti-Rabbit IgG: HRP at 1:5000 for 1 hour at RT.
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Description

MDM2 Antibody

MDM2 Antibody is a rabbit polyclonal antibody directed against MDM2, offered by Assay Genie for research applications. Reported applications include WB and IHC. Reported reactivity: Human, Mouse and Rat. Purified by Peptide Affinity.

MDM2 (Mouse Double Minute 2 homolog) is an E3 ubiquitin ligase that negatively regulates the tumor suppressor p53, controlling its stability and transcriptional activity. In the nervous system, MDM2-p53 signaling is crucial for balancing neuronal survival and apoptosis. Overactivation of p53, due to MDM2 dysfunction, can lead to excessive neuronal loss—a feature observed in neurodegenerative diseases such as Parkinson’s and ALS. MDM2 also influences synaptic plasticity and neurogenesis, suggesting broader roles in cognitive function and brain repair. Targeting the MDM2-p53 axis offers a potential neuroprotective strategy by modulating stress responses and preventing p53-mediated neurotoxicity in degenerative conditions. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.

Product Name:MDM2 Antibody
Product SKU:STPA00083
Size:100 µg
Target:MDM2
Host Species:Rabbit
Antibody Type:Polyclonal
Research Areas:Cancer, Cell Cycle, p53 Pathway, Cell Signaling, Epigenetics and Nuclear Signaling, Cancer, Tumor Biomarkers, Oncoproteins
Buffer:PBS pH 7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:Liquid
Applications:WB, IHC
Purification:Peptide Affinity Purified
Concentration:1 mg/ml
Reactivity:Human, Mouse, Rat
Recommended Dilution:WB (1:1000); IHC (1:50); optimal dilutions for assays should be determined by the user.
Specificity:Detects ~50 kDa. ~50 kDa band is isoform 2 or 3.
Guarantee:12 months from date of dispatch
Immunogen:Synthetic peptide from the mid-protein of Human MDM2 (aa. 100-200)
Immunogen Species:Human
Accession Number:NP_001138811.1
Gene ID:4193
Swiss-Prot:Q00987
Cellular Localization:Nucleus | Nucleoplasm | Cytoplasm | Nucleus | Nucleolus
Tissue Specificity:Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues.
Alternative Names:MDM2, Double minute 2 protein, Hdm2, MTBP, Mouse Double Minute 2, HDMX, ACTFS, p53 Binding Protein Mdm2, Ubiquitin protein ligase E3 Mdm2, Mdm2 p53 E3 ubiquitin protein ligase homolog, MDM2BP, p53-binding protein Mdm2, Oncoprotein Mdm2, Hdm 2, E3 ubiquitin-protein ligase Mdm2, MDM 2, EC:6.3.2.-, MDM2_HUMAN, MDM2 oncogene E3 ubiquitin protein ligase, Murine Double Minute Chromosome 2, Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa
Note:For research use only.
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