Cell Biology Antibodies 10

Anti-MATK Antibody (CAB6651)

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SKU:
CAB6651
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MATK Antibody
Antibody SKU:CAB6651
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 352-466 of human MATK (NP_647611.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:THP-1
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 352-466 of human MATK (NP_647611.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PEAL KHGK FTSK SDVW SFGV LLWE VFSY GRAP YPKM SLKE VSEA VEKG YRME PPEG CPGP VHVL MSSC WEAE PARR PPFR KLAE KLAR ELRS AGAP ASVS GQDA DGST SPRS QEP
Gene ID:4145
Uniprot:P42679
Cellular Location:Cytoplasm, Membrane
Calculated MW:51kDa/56kDa
Observed MW:56kDa
Synonyms:MATK, CHK, CTK, HHYLTK, HYL, HYLTK, Lsk
Background:The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.
NCBI Summary:The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P42679
NCBI GenInfo Identifier:
NCBI Gene ID:4145
NCBI Accession:
UniProt Related Accession:P42679
Molecular Weight:Observed MW: 56kDa
NCBI Full Name:
NCBI Synonym Full Names:megakaryocyte-associated tyrosine kinase
NCBI Official Symbol:MATK  
NCBI Official Synonym Symbols:CHK; CTK; HYL; Lsk; HYLTK; HHYLTK  
NCBI Protein Information:megakaryocyte-associated tyrosine-protein kinase
UniProt Protein Name:
Protein Family:Maturase
UniProt Gene Name:
Anti-MATK Antibody (CAB6651)Western blot analysis of extracts of THP-1 cells, using MATK antibody (CAB6651) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-MATK Antibody (CAB6651)Immunohistochemistry of paraffin-embedded rat kidney using MATK antibody (CAB6651) at dilution of 1:100 (40x lens).
Anti-MATK Antibody (CAB6651)Immunohistochemistry of paraffin-embedded mouse kidney using MATK antibody (CAB6651) at dilution of 1:100 (40x lens).
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