Cell Biology Antibodies 10
Anti-MATK Antibody (CAB6651)
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- SKU:
- CAB6651
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MATK Antibody |
| Antibody SKU: | CAB6651 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 352-466 of human MATK (NP_647611.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | THP-1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 352-466 of human MATK (NP_647611.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PEAL KHGK FTSK SDVW SFGV LLWE VFSY GRAP YPKM SLKE VSEA VEKG YRME PPEG CPGP VHVL MSSC WEAE PARR PPFR KLAE KLAR ELRS AGAP ASVS GQDA DGST SPRS QEP |
| Gene ID: | 4145 |
| Uniprot: | P42679 |
| Cellular Location: | Cytoplasm, Membrane |
| Calculated MW: | 51kDa/56kDa |
| Observed MW: | 56kDa |
| Synonyms: | MATK, CHK, CTK, HHYLTK, HYL, HYLTK, Lsk |
| Background: | The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. |
| NCBI Summary: | The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P42679 |
| NCBI GenInfo Identifier: | |
| NCBI Gene ID: | 4145 |
| NCBI Accession: | |
| UniProt Related Accession: | P42679 |
| Molecular Weight: | Observed MW: 56kDa |
| NCBI Full Name: | |
| NCBI Synonym Full Names: | megakaryocyte-associated tyrosine kinase |
| NCBI Official Symbol: | MATK |
| NCBI Official Synonym Symbols: | CHK; CTK; HYL; Lsk; HYLTK; HHYLTK |
| NCBI Protein Information: | megakaryocyte-associated tyrosine-protein kinase |
| UniProt Protein Name: | |
| Protein Family: | Maturase |
| UniProt Gene Name: |
 | Western blot analysis of extracts of THP-1 cells, using MATK antibody (CAB6651) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using MATK antibody (CAB6651) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using MATK antibody (CAB6651) at dilution of 1:100 (40x lens). |
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