Cell Biology Antibodies 4

Anti-MAN1A2 Antibody (CAB14271)

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SKU:
CAB14271
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MAN1A2 Antibody
Antibody SKU:CAB14271
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human MAN1A2 (NP_006690.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:LO2, A-549, Mouse brain, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human MAN1A2 (NP_006690.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SSKH KRFD LGLE DVLI PHVD AGKG AKNP GVFL IHGP DEHR HREE EERL RNKI RADH EKAL EEAK EKLR KSRE EIRA EIQT EKNK VVQE MKIK ENKP LPPV PIPN LVGI RGGD PEDN DIRE K
Gene ID:10905
Uniprot:O60476
Cellular Location:Golgi apparatus membrane, Single-pass type II membrane protein
Calculated MW:73kDa
Observed MW:73kDa
Synonyms:MAN1A2, MAN1B
Background:
UniProt Protein Function:MAN1A2: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). Belongs to the glycosyl hydrolase 47 family.
UniProt Protein Details:

Protein type:Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; EC 3.2.1.113; Hydrolase

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: endoplasmic reticulum; Golgi apparatus; Golgi membrane; membrane

Molecular Function:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Biological Process: N-glycan processing

NCBI Summary:Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008]
UniProt Code:O60476
NCBI GenInfo Identifier:17368019
NCBI Gene ID:10905
NCBI Accession:O60476.1
UniProt Secondary Accession:O60476,Q9H510,
UniProt Related Accession:O60476
Molecular Weight:73,004 Da
NCBI Full Name:Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
NCBI Synonym Full Names:mannosidase alpha class 1A member 2
NCBI Official Symbol:MAN1A2  
NCBI Official Synonym Symbols:MAN1B  
NCBI Protein Information:mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
UniProt Protein Name:Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
UniProt Synonym Protein Names:Mannosidase alpha class 1A member 2; Processing alpha-1,2-mannosidase IB; Alpha-1,2-mannosidase IB
Protein Family:Mannosyl-oligosaccharide 1,2-alpha-mannosidase
UniProt Gene Name:MAN1A2  
UniProt Entry Name:MA1A2_HUMAN
Anti-MAN1A2 Antibody (CAB14271)Western blot analysis of extracts of various cell lines, using MAN1A2 antibody (CAB14271) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-MAN1A2 Antibody (CAB14271)Immunohistochemistry of paraffin-embedded Human colon carcinoma using MAN1A2 Rabbit pAb (CAB14271) at dilution of 1:100 (40x lens).
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