Cell Biology Antibodies 14

Anti-MAGEA3 Antibody (CAB16915)

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SKU:
CAB16915
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MAGEA3 Antibody
Antibody SKU:CAB16915
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human MAGEA3.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, Mouse brain, Rat brain
Immunogen:A synthetic peptide of human MAGEA3.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4102
Uniprot:P43357
Cellular Location:
Calculated MW:
Observed MW:42kDa
Anti-MAGEA3 Antibody (CAB16915)Western blot - MAGEA3 Rabbit pAb (CAB16915)
Synonyms:MAGEA3, CT1.3, HIP8, HYPD, MAGE3, MAGEA6
Background:This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.
UniProt Protein Function:MAGEA3: Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
UniProt Protein Details:

Protein type:Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: endoplasmic reticulum

Molecular Function:protein binding

Biological Process: negative regulation of caspase activity

NCBI Summary:This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]
UniProt Code:P43357
NCBI GenInfo Identifier:1170857
NCBI Gene ID:4102
NCBI Accession:P43357.1
UniProt Secondary Accession:P43357,Q6FHI6,
UniProt Related Accession:P43357
Molecular Weight:34,747 Da
NCBI Full Name:Melanoma-associated antigen 3
NCBI Synonym Full Names:MAGE family member A3
NCBI Official Symbol:MAGEA3  
NCBI Official Synonym Symbols:HIP8; HYPD; CT1.3; MAGE3; MAGEA6  
NCBI Protein Information:melanoma-associated antigen 3
UniProt Protein Name:Melanoma-associated antigen 3
UniProt Synonym Protein Names:Antigen MZ2-D; Cancer/testis antigen 1.3; CT1.3; MAGE-3 antigen
Protein Family:Melanoma-associated antigen
UniProt Gene Name:MAGEA3  
UniProt Entry Name:MAGA3_HUMAN
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