Anti-MAGE-1/MAGE1A Antibody (CAB0723)
- SKU:
- CAB0723
Description
| Product Name: | MAGE-1/MAGE1A Rabbit mAb |
| Product Code: | CAB0723 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CT1.1, MAGE1 |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human MAGE-1/MAGE1A |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, A-549, A375, Mouse lung, Mouse testis |
| Immunogen: | A synthesized peptide derived from human MAGE-1/MAGE1A |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4100 |
| Uniprot: | P43355 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 46kDa |
| Observed MW: | 51kDa |
| UniProt Protein Function: | MAGE-A1: a tumor antigen expressed in a variety of tumor cells and in the testis. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. |
| UniProt Protein Details: | Protein type:Cell surface Chromosomal Location of Human Ortholog: Xq28 Cellular Component: cytoplasm; plasma membrane; nucleus Molecular Function:protein binding; histone deacetylase binding Biological Process: transcription, DNA-dependent; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P43355 |
| NCBI GenInfo Identifier: | 1170855 |
| NCBI Gene ID: | 4100 |
| NCBI Accession: | P43355.1 |
| UniProt Secondary Accession: | P43355,O00346, B2RC81, |
| UniProt Related Accession: | P43355,AAB33086 |
| Molecular Weight: | 309 |
| NCBI Full Name: | Melanoma-associated antigen 1 |
| NCBI Synonym Full Names: | melanoma antigen family A, 1 (directs expression of antigen MZ2-E) |
| NCBI Official Symbol: | MAGEA1 |
| NCBI Official Synonym Symbols: | CT1.1; MAGE1 |
| NCBI Protein Information: | melanoma-associated antigen 1; antigen MZ2-E; MAGE-1 antigen; melanoma antigen MAGE-1; cancer/testis antigen 1.1; melanoma antigen family A 1; melanoma-associated antigen MZ2-E; cancer/testis antigen family 1, member 1 |
| UniProt Protein Name: | Melanoma-associated antigen 1 |
| UniProt Synonym Protein Names: | Antigen MZ2-E; Cancer/testis antigen 1.1; CT1.1; MAGE-1 antigen |
| Protein Family: | Melanoma-associated antigen |
| UniProt Gene Name: | MAGEA1 |
| UniProt Entry Name: | MAGA1_HUMAN |
Additional Information
Product Type: |
Antibody |
Antibody Type: |
Monoclonal Antibody |
Reactivity: |
Human |
Reactivity: |
Mouse |
Host Species: |
Rabbit |
Isotype: |
IgG |
Synonyms: |
CT1.1 |
Synonyms: |
MAGE1 |
Research Area: |
Epigenetics and Nuclear Signaling |
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