Cell Biology Antibodies 15
Anti-MAFA Antibody (CAB18662)
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- SKU:
- CAB18662
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MAFA Antibody |
| Antibody SKU: | CAB18662 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human MAFA. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant protein of human MAFA. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 389692 |
| Uniprot: | Q8NHW3 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | |
| Background: |
| UniProt Protein Function: | MAFA: Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds DNA as a homodimer (Probable). Interacts with NEUROD1, PCAF and PDX1. Up-regulated by glucose. Belongs to the bZIP family. Maf subfamily. |
| UniProt Protein Details: | Protein type:DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: nucleus Molecular Function:DNA binding; protein homodimerization activity; transcription factor activity Biological Process: insulin secretion; nitric oxide mediated signal transduction; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to glucose stimulus |
| NCBI Summary: | MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8NHW3 |
| NCBI GenInfo Identifier: | 296435511 |
| NCBI Gene ID: | 389692 |
| NCBI Accession: | Q8NHW3.2 |
| UniProt Related Accession: | Q8NHW3 |
| Molecular Weight: | 36,982 Da |
| NCBI Full Name: | Transcription factor MafA |
| NCBI Synonym Full Names: | MAF bZIP transcription factor A |
| NCBI Official Symbol: | MAFA |
| NCBI Official Synonym Symbols: | hMafA; RIPE3b1 |
| NCBI Protein Information: | transcription factor MafA |
| UniProt Protein Name: | Transcription factor MafA |
| UniProt Synonym Protein Names: | Pancreatic beta-cell-specific transcriptional activator; Transcription factor RIPE3b1; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | MAFA |
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