Cell Cycle Antibodies 2

Anti-MAD1 Antibody (CAB5098)

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SKU:
CAB5098
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-MAD1 Antibody
Antibody SKU:CAB5098
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human MAD1
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, 294T, Mouse spleen
Immunogen:A synthesized peptide derived from human MAD1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8379
Uniprot:Q9Y6D9
Cellular Location:
Calculated MW:80kDa
Observed MW:83KDa
Synonyms:MAD1, PIG9, TP53I9, TXBP181
Background:MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
UniProt Protein Function:MAD1L1: a component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Expressed weakly at G0/G1 and highly at late S and G2/M phase. Induced by p53. Becomes hyperphosphorylated in late S through M phases or after mitotic spindle damage. Two alternatively spliced isoforms have been described. Defects in MAD1L1 are involved in the development and/or progression of various types of cancer.
UniProt Protein Details:

Protein type:Cell cycle regulation; Cytoskeletal

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: kinetochore; centrosome; cytoplasm; spindle; nuclear pore; nucleus; cytosol; actin cytoskeleton

Molecular Function:protein binding

Biological Process: mitosis; cell division; mitotic cell cycle checkpoint; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle

Disease: Prostate Cancer

NCBI Summary:MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y6D9
NCBI GenInfo Identifier:52783153
NCBI Gene ID:8379
NCBI Accession:Q9Y6D9.2
UniProt Secondary Accession:Q9Y6D9,Q13312, Q75MI0, Q86UM4, Q9UNH0, B3KR41,
UniProt Related Accession:Q9Y6D9
Molecular Weight:718
NCBI Full Name:Mitotic spindle assembly checkpoint protein MAD1
NCBI Synonym Full Names:MAD1 mitotic arrest deficient-like 1 (yeast)
NCBI Official Symbol:MAD1L1  
NCBI Official Synonym Symbols:MAD1; PIG9; TP53I9; TXBP181  
NCBI Protein Information:mitotic spindle assembly checkpoint protein MAD1; MAD1-like protein 1; tax-binding protein 181; tumor protein p53 inducible protein 9; mitotic checkpoint MAD1 protein homolog; mitotic arrest deficient 1-like protein 1; mitotic-arrest deficient 1, yeast, homolog-like 1
UniProt Protein Name:Mitotic spindle assembly checkpoint protein MAD1
UniProt Synonym Protein Names:Mitotic arrest deficient 1-like protein 1; MAD1-like protein 1; Mitotic checkpoint MAD1 protein homolog; HsMAD1; hMAD1; Tax-binding protein 181
Protein Family:Mitotic spindle assembly checkpoint protein
UniProt Gene Name:MAD1L1  
UniProt Entry Name:MD1L1_HUMAN
Anti-MAD1 Antibody (CAB5098)Western blot - MAD1 Rabbit mAb (CAB5098)
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