Immunology Antibodies 2
Anti-LYN Antibody (CAB2093)
- SKU:
- CAB2093
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-LYN Antibody |
| Antibody SKU: | CAB2093 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human LYN (NP_002341.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, HeLa, K-562, Mouse lung, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human LYN (NP_002341.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGCI KSKG KDSL SDDG VDLK TQPV RNTE RTIY VRDP TSNK QQRP VPES QLLP GQRF QTKD PEEQ GDIV VALY PYDG IHPD DLSF KKGE KMKV LEEH GEWW KAKS LLTK KEGF IPSN YVAK LNTL ETEE WFFK DITR KDAE RQLL APGN SAGA FLIR ESET LKGS FSLS VRDF DPVH GDVI KHYK IRSL DNGG YYIS PRIT FPCI SDMI KHYQ KQAD GLCR RLEK ACIS PKPQ KPWD KDAW |
| Gene ID: | 4067 |
| Uniprot: | P07948 |
| Cellular Location: | Cell membrane, Cytoplasm, Golgi apparatus, Lipid-anchor, Membrane, Nucleus, perinuclear region |
| Calculated MW: | 56kDa/58kDa |
| Observed MW: | 55kDa |
| Synonyms: | LYN, JTK8, p53Lyn, p56Lyn |
| Background: | This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | LYN: a tyrosine kinase of the Src family that plays a role in B cell antigen-receptor signaling. |
| UniProt Protein Details: | Protein type:Protein kinase, tyrosine (non-receptor); Kinase, protein; Oncoprotein; Protein kinase, TK; EC 2.7.10.2; TK group; Src family Chromosomal Location of Human Ortholog: 8q13 Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; Golgi apparatus; lipid raft; mast cell granule; mitochondrial crista; mitochondrial intermembrane space; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density Molecular Function:ATP binding; enzyme binding; gamma-tubulin binding; glycosphingolipid binding; integrin binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; platelet-derived growth factor receptor binding; protein binding; protein-tyrosine kinase activity; receptor binding; receptor signaling protein tyrosine kinase activity; SH3 domain binding; ubiquitin protein ligase binding Biological Process: adaptive immune response; axon guidance; B cell homeostasis; B cell receptor signaling pathway; blood coagulation; cellular response to extracellular stimulus; cytokine secretion; ephrin receptor signaling pathway; erythrocyte differentiation; Fc receptor mediated inhibitory signaling pathway; Fc receptor mediated stimulatory signaling pathway; histamine secretion by mast cell; immune response-regulating cell surface receptor signaling pathway; innate immune response; leukocyte migration; lipopolysaccharide-mediated signaling pathway; negative regulation of B cell proliferation; negative regulation of cell proliferation; negative regulation of immune response; negative regulation of MAP kinase activity; negative regulation of myeloid leukocyte differentiation; negative regulation of protein amino acid phosphorylation; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; neurite development; oligodendrocyte development; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; positive regulation of B cell receptor signaling pathway; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of tyrosine phosphorylation of STAT protein; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of B cell apoptosis; regulation of B cell receptor signaling pathway; regulation of cell adhesion mediated by integrin; regulation of cytokine production; regulation of cytokine secretion; regulation of erythrocyte differentiation; regulation of inflammatory response; regulation of mast cell activation; regulation of mast cell degranulation; regulation of protein amino acid phosphorylation; regulation of release of sequestered calcium ion into cytosol; response to amino acid stimulus; response to axon injury; response to carbohydrate stimulus; response to DNA damage stimulus; response to drug; response to hormone stimulus; response to insulin stimulus; response to organic cyclic substance; response to sterol depletion; response to toxin; signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; tolerance induction to self antigen; transmembrane receptor protein tyrosine kinase signaling pathway; viral reproduction |
| NCBI Summary: | This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] |
| UniProt Code: | P07948 |
| NCBI GenInfo Identifier: | 125480 |
| NCBI Gene ID: | 4067 |
| NCBI Accession: | P07948.3 |
| UniProt Secondary Accession: | P07948,A0AVQ5, |
| UniProt Related Accession: | P07948 |
| Molecular Weight: | 56,033 Da |
| NCBI Full Name: | Tyrosine-protein kinase Lyn |
| NCBI Synonym Full Names: | LYN proto-oncogene, Src family tyrosine kinase |
| NCBI Official Symbol: | LYN |
| NCBI Official Synonym Symbols: | JTK8; p53Lyn; p56Lyn |
| NCBI Protein Information: | tyrosine-protein kinase Lyn |
| UniProt Protein Name: | Tyrosine-protein kinase Lyn |
| UniProt Synonym Protein Names: | Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn |
| Protein Family: | Tyrosine-protein kinase |
| UniProt Gene Name: | LYN |
| UniProt Entry Name: | LYN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LYN antibody (CAB2093) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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