Cell Death Antibodies 1
Anti-LTBR Antibody (CAB12006)
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- SKU:
- CAB12006
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-LTBR Antibody |
| Antibody SKU: | CAB12006 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 249-435 of human LTBR (NP_002333.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 249-435 of human LTBR (NP_002333.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KSHP SLCR KLGS LLKR RPQG EGPN PVAG SWEP PKAH PYFP DLVQ PLLP ISGD VSPV STGL PAAP VLEA GVPQ QQSP LDLT REPQ LEPG EQSQ VAHG TNGI HVTG GSMT ITGN IYIY NGPV LGGP PGPG DLPA TPEP PYPI PEEG DPGP PGLS TPHQ EDGK AWHL AETE HCGA TPSN RGPR NQFI THD |
| Gene ID: | 4055 |
| Uniprot: | P36941 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 44kDa/46kDa |
| Observed MW: | 47kDa |
| Synonyms: | LTBR, CD18, D12S370, LT-BETA-R, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFR3, TNFRSF3 |
| Background: | This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. |
| UniProt Protein Function: | LTBR: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13 Cellular Component: integral to membrane Molecular Function:identical protein binding; protein binding; ubiquitin protein ligase binding Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; apoptosis; positive regulation of JNK cascade; myeloid dendritic cell differentiation; signal transduction |
| NCBI Summary: | This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012] |
| UniProt Code: | P36941 |
| NCBI GenInfo Identifier: | 549090 |
| NCBI Gene ID: | 4055 |
| NCBI Accession: | P36941.1 |
| UniProt Secondary Accession: | P36941,B7Z1D2, D3DUR2, F5GXE7, |
| UniProt Related Accession: | P36941 |
| Molecular Weight: | 435 |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 3 |
| NCBI Synonym Full Names: | lymphotoxin beta receptor (TNFR superfamily, member 3) |
| NCBI Official Symbol: | LTBR |
| NCBI Official Synonym Symbols: | CD18; TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 3; lymphotoxin B receptor; tumor necrosis factor C receptor; tumor necrosis factor receptor type III; tumor necrosis factor receptor 2-related protein |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 3 |
| UniProt Synonym Protein Names: | Lymphotoxin-beta receptor; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; Tumor necrosis factor receptor type III; TNF-RIII; TNFR-III |
| Protein Family: | Tumor necrosis factor receptor superfamily |
| UniProt Gene Name: | LTBR |
| UniProt Entry Name: | TNR3_HUMAN |
 | Western blot analysis of extracts of mouse liver, using LTBR Antibody (CAB12006) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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