Cell Biology Antibodies 15

Anti-LRRK1 Antibody (CAB17768)

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SKU:
CAB17768
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-LRRK1 Antibody
Antibody SKU:CAB17768
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 10-90 of human LRRK1 (NP_078928.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:Raji
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 10-90 of human LRRK1 (NP_078928.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SMYW CVGP EESA VCPE RAME TLNG AGDT GGKP STRG GDPA ARSR RTEG IRAA YRRG DRGG ARDL LEEA CDQC ASQL EKGQ L
Gene ID:79705
Uniprot:Q38SD2
Cellular Location:
Calculated MW:
Observed MW:250kDa
Anti-LRRK1 Antibody (CAB17768)Western blot - LRRK1 Polyclonal Antibody (CAB17768)
Synonyms:RIPK6, Roco1, LRRK1
Background:This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
UniProt Protein Function:LRRK1: a large multidomain protein kinase with a TKL-type kinase domain, multiple protein-protein interaction domains and a mitochondrial Rho domain (MIRO). Involved in the trafficking of epidermal growth factor (EGFR) from early to late endosomes. Forms a complex with activated EGFR via the adaptor protein Grb2. Subsequently, LRRK1 and EGFR are internalized and co-localized in early endosomes. LRRK1 is phosphorylated by EGFR, inhibiting its kinase activity. The reduction of kinase activity plays an important role in endosomal trafficking of the EGFR. Serves as a scaffold expediting the interaction of EGFR with the endosomal sorting complex required for efficient sorting of EGFR to the inner vesicles of multivesicular bodies. Plays a critical role in negative regulation of bone mass in part through modulating the c-Src signaling pathway in mice. Phosphorylation of c-Src at Tyr-527 is significantly elevated whereas at Tyr-416 is decreased in LRRK1 KO mouse osteoclasts.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, TKL; TKL group; LRRK family

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: cytoplasm; mitochondrion

Molecular Function:identical protein binding; protein binding

UniProt Code:Q38SD2
NCBI GenInfo Identifier:313104220
NCBI Gene ID:79705
NCBI Accession:Q38SD2.3
UniProt Secondary Accession:Q38SD2,Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3
UniProt Related Accession:Q38SD2
Molecular Weight:28,848 Da
NCBI Full Name:Leucine-rich repeat serine/threonine-protein kinase 1
NCBI Synonym Full Names:leucine rich repeat kinase 1
NCBI Official Symbol:LRRK1  
NCBI Official Synonym Symbols:RIPK6; Roco1  
NCBI Protein Information:leucine-rich repeat serine/threonine-protein kinase 1
UniProt Protein Name:Leucine-rich repeat serine/threonine-protein kinase 1
Protein Family:Leucine-rich repeat serine/threonine-protein kinase
UniProt Gene Name:LRRK1  
UniProt Entry Name:LRRK1_HUMAN
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