Cell Biology Antibodies 15
Anti-LRRK1 Antibody (CAB17768)
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- SKU:
- CAB17768
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LRRK1 Antibody |
| Antibody SKU: | CAB17768 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 10-90 of human LRRK1 (NP_078928.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | Raji |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 10-90 of human LRRK1 (NP_078928.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SMYW CVGP EESA VCPE RAME TLNG AGDT GGKP STRG GDPA ARSR RTEG IRAA YRRG DRGG ARDL LEEA CDQC ASQL EKGQ L |
| Gene ID: | 79705 |
| Uniprot: | Q38SD2 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 250kDa |
 | Western blot - LRRK1 Polyclonal Antibody (CAB17768) |
| Synonyms: | RIPK6, Roco1, LRRK1 |
| Background: | This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017] |
| UniProt Protein Function: | LRRK1: a large multidomain protein kinase with a TKL-type kinase domain, multiple protein-protein interaction domains and a mitochondrial Rho domain (MIRO). Involved in the trafficking of epidermal growth factor (EGFR) from early to late endosomes. Forms a complex with activated EGFR via the adaptor protein Grb2. Subsequently, LRRK1 and EGFR are internalized and co-localized in early endosomes. LRRK1 is phosphorylated by EGFR, inhibiting its kinase activity. The reduction of kinase activity plays an important role in endosomal trafficking of the EGFR. Serves as a scaffold expediting the interaction of EGFR with the endosomal sorting complex required for efficient sorting of EGFR to the inner vesicles of multivesicular bodies. Plays a critical role in negative regulation of bone mass in part through modulating the c-Src signaling pathway in mice. Phosphorylation of c-Src at Tyr-527 is significantly elevated whereas at Tyr-416 is decreased in LRRK1 KO mouse osteoclasts. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, TKL; TKL group; LRRK family Chromosomal Location of Human Ortholog: 15q26.3 Cellular Component: cytoplasm; mitochondrion Molecular Function:identical protein binding; protein binding |
| UniProt Code: | Q38SD2 |
| NCBI GenInfo Identifier: | 313104220 |
| NCBI Gene ID: | 79705 |
| NCBI Accession: | Q38SD2.3 |
| UniProt Secondary Accession: | Q38SD2,Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3 |
| UniProt Related Accession: | Q38SD2 |
| Molecular Weight: | 28,848 Da |
| NCBI Full Name: | Leucine-rich repeat serine/threonine-protein kinase 1 |
| NCBI Synonym Full Names: | leucine rich repeat kinase 1 |
| NCBI Official Symbol: | LRRK1 |
| NCBI Official Synonym Symbols: | RIPK6; Roco1 |
| NCBI Protein Information: | leucine-rich repeat serine/threonine-protein kinase 1 |
| UniProt Protein Name: | Leucine-rich repeat serine/threonine-protein kinase 1 |
| Protein Family: | Leucine-rich repeat serine/threonine-protein kinase |
| UniProt Gene Name: | LRRK1 |
| UniProt Entry Name: | LRRK1_HUMAN |
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