Cell Biology Antibodies 4
Anti-LRP1 Antibody (CAB13509)
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- SKU:
- CAB13509
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LRP1 Antibody |
| Antibody SKU: | CAB13509 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-270 of human LRP1 (NP_002323.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse lung, Mouse liver, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-270 of human LRP1 (NP_002323.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AIDA PKTC SPKQ FACR DQIT CISK GWRC DGER DCPD GSDE APEI CPQS KAQR CQPN EHNC LGTE LCVP MSRL CNGV QDCM DGSD EGPH CREL QGNC SRLG CQHH CVPT LDGP TCYC NSSF QLQA DGKT CKDF DECS VYGT CSQL CTNT DGSF ICGC VEGY LLQP DNRS CKAK NEPV DRPP VLLI ANSQ NILA TYLS GAQV STIT PTST RQTT AMDF SYAN ETVC WVHV GDSA AQTQ LKCA RMPG LKGF VDE |
| Gene ID: | 4035 |
| Uniprot: | Q07954 |
| Cellular Location: | Cell membrane, Cytoplasm, Extracellular side, Membrane, Nucleus, Peripheral membrane protein, Single-pass type I membrane protein, coated pit |
| Calculated MW: | 31kDa/504kDa |
| Observed MW: | 85kDa |
| Synonyms: | LRP1, A2MR, APOER, APR, CD91, IGFBP3R, KPA, LRP, LRP1A, TGFBR5 |
| Background: | This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. |
| UniProt Protein Function: | LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cell surface; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 12q13.3 Cellular Component: focal adhesion; cell soma; clathrin-coated vesicle; lysosomal membrane; integral to plasma membrane; dendrite; cytoplasm; plasma membrane; nucleolus; coated pit; endosome; receptor complex Molecular Function:protein binding; lipoprotein transporter activity; protease binding; protein complex binding; apolipoprotein binding; calcium ion binding; receptor activity Biological Process: positive regulation of protein transport; receptor-mediated endocytosis; cell proliferation; positive regulation of lipid transport; cholesterol metabolic process; phototransduction, visible light; regulation of phospholipase A2 activity; negative regulation of Wnt receptor signaling pathway; lipoprotein transport; regulation of actin cytoskeleton organization and biogenesis; protein kinase C activation; lipoprotein metabolic process; negative regulation of neuron apoptosis; negative regulation of smooth muscle cell migration; retinoid metabolic process; regulation of cholesterol transport; apoptotic cell clearance; aging |
| NCBI Summary: | The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010] |
| UniProt Code: | Q07954 |
| NCBI GenInfo Identifier: | 317373384 |
| NCBI Gene ID: | 4035 |
| NCBI Accession: | Q07954.2 |
| UniProt Secondary Accession: | Q07954,Q2PP12, Q86SW0, Q8IVG8, |
| UniProt Related Accession: | Q07954 |
| Molecular Weight: | |
| NCBI Full Name: | Prolow-density lipoprotein receptor-related protein 1 |
| NCBI Synonym Full Names: | low density lipoprotein receptor-related protein 1 |
| NCBI Official Symbol: | LRP1 |
| NCBI Official Synonym Symbols: | APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R |
| NCBI Protein Information: | prolow-density lipoprotein receptor-related protein 1; LRP-1; type V tgf-beta receptor; apolipoprotein E receptor; alpha-2-macroglobulin receptor; TbetaR-V/LRP-1/IGFBP-3 receptor |
| UniProt Protein Name: | Prolow-density lipoprotein receptor-related protein 1 |
| UniProt Synonym Protein Names: | Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD_antigen: CD91Cleaved into the following 3 chains:Low-density lipoprotein receptor-related protein 1 85 kDa subunit; LRP-85; Low-density lipoprotein receptor-related protein 1 515 kDa subunit; LRP-515; Low-density lipoprotein receptor-related protein 1 intracellular domain; LRPICD |
| Protein Family: | Low-density lipoprotein receptor-related protein |
| UniProt Gene Name: | LRP1 |
| UniProt Entry Name: | LRP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LRP1 Rabbit pAb (CAB13509) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
 | Immunofluorescence analysis of U2OS cells using LRP1 antibody (CAB13509). Blue: DAPI for nuclear staining. |
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