Signal Transduction Antibodies 1

Anti-LNX1 Antibody (CAB14517)

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SKU:
CAB14517
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-LNX1 Antibody
Antibody SKU:CAB14517
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 480-620 of human LNX1 (NP_001119800.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 480-620 of human LNX1 (NP_001119800.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NGSW SPGP GERS NTPK PLHP TITC HEKV VNIQ KDPG ESLG MTVA GGAS HREW DLPI YVIS VEPG GVIS RDGR IKTG DILL NVDG VELT EVSR SEAV ALLK RTSS SIVL KALE VKEY EPQE DCSS PAAL DSNH NMAP PSDW S
Gene ID:84708
Uniprot:Q8TBB1
Cellular Location:Cytoplasm
Calculated MW:69kDa/80kDa
Observed MW:Refer to Figures
Synonyms:LNX1, LNX, MPDZ, PDZRN2
Background:This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene.
UniProt Protein Function:LNX1: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 6.3.2.-; Ubiquitin ligase; Adaptor/scaffold; Ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: cytoplasm

Molecular Function:protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity; PDZ domain binding

Biological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process; protein homooligomerization

NCBI Summary:This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q8TBB1
NCBI GenInfo Identifier:29840786
NCBI Gene ID:84708
NCBI Accession:Q8TBB1.1
UniProt Secondary Accession:Q8TBB1,Q4W5K7, Q8N4C2, Q96MJ7, Q9BY20,
UniProt Related Accession:Q8TBB1
Molecular Weight:728
NCBI Full Name:E3 ubiquitin-protein ligase LNX
NCBI Synonym Full Names:ligand of numb-protein X 1, E3 ubiquitin protein ligase
NCBI Official Symbol:LNX1  
NCBI Official Synonym Symbols:LNX; MPDZ; PDZRN2  
NCBI Protein Information:E3 ubiquitin-protein ligase LNX; numb-binding protein 1; PDZ domain-containing ring finger protein 2; multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX
UniProt Protein Name:E3 ubiquitin-protein ligase LNX
UniProt Synonym Protein Names:Ligand of Numb-protein X 1; Numb-binding protein 1; PDZ domain-containing RING finger protein 2
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:LNX1  
UniProt Entry Name:LNX1_HUMAN
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