Developmental Biology
Anti-LHX1 Antibody (CAB17344)
- SKU:
- CAB17344
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-LHX1 Antibody |
| Antibody SKU: | CAB17344 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-180 of human LHX1 (NP_005559.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, Mouse testis, Mouse brain, Rat testis, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-180 of human LHX1 (NP_005559.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SNSS VAKE NSLH SATT GSDP SLSP DSQD PSQD DAKD SESA NVSD KEAG SNEN DDQN LGAK R |
| Gene ID: | 3975 |
| Uniprot: | P48742 |
| Cellular Location: | Nucleus |
| Calculated MW: | 44kDa |
| Observed MW: | 52kDa |
| Synonyms: | LHX1, LIM-1, LIM1 |
| Background: | This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract. |
| UniProt Protein Function: | LHX1: Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. |
| UniProt Protein Details: | Protein type:Transcription factor; Cell development/differentiation Chromosomal Location of Human Ortholog: 17q12 Cellular Component: protein complex; nucleus Molecular Function:zinc ion binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; motor axon guidance; uterus development; forebrain regionalization; embryonic pattern specification; pronephros development; post-embryonic development; anterior/posterior pattern formation; cell-cell signaling; ectoderm formation; ureteric bud development; anatomical structure formation; cerebellum development; kidney development; fallopian tube development; cervix development; nervous system development; anatomical structure morphogenesis; vagina development; ventral spinal cord development; gastrulation with mouth forming second; embryonic viscerocranium morphogenesis; somite rostral/caudal axis specification; pattern specification process; Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation; organ morphogenesis; telencephalon development; positive regulation of embryonic development; dorsal/ventral pattern formation; regulation of gene expression; endoderm formation; ureteric bud branching; embryonic retina morphogenesis in camera-type eye; cerebellar Purkinje cell differentiation; spinal cord association neuron differentiation; negative regulation of transcription, DNA-dependent; urogenital system development; anterior/posterior axis specification |
| NCBI Summary: | This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract. [provided by RefSeq, Dec 2010] |
| UniProt Code: | P48742 |
| NCBI GenInfo Identifier: | 30410785 |
| NCBI Gene ID: | 3975 |
| NCBI Accession: | NP_005559 |
| UniProt Related Accession: | P48742 |
| Molecular Weight: | 45kDa |
| NCBI Full Name: | LIM/homeobox protein Lhx1 |
| NCBI Synonym Full Names: | LIM homeobox 1 |
| NCBI Official Symbol: | LHX1 |
| NCBI Official Synonym Symbols: | LIM1; LIM-1 |
| NCBI Protein Information: | LIM/homeobox protein Lhx1 |
| UniProt Protein Name: | LIM/homeobox protein Lhx1 |
| UniProt Synonym Protein Names: | Homeobox protein Lim-1 |
| UniProt Gene Name: | LHX1 |
| UniProt Entry Name: | LHX1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LHX1 antibody (CAB17344) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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