Cell Biology Antibodies 8
Anti-LHB Antibody (CAB3000)
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- SKU:
- CAB3000
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LHB Antibody |
| Antibody SKU: | CAB3000 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human LHB |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | K-562 |
| Immunogen: | A synthetic peptide of human LHB |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3972 |
| Uniprot: | P01229 |
| Cellular Location: | Secreted |
| Calculated MW: | 15kDa |
| Observed MW: | 18kDa |
| Synonyms: | LHB, CGB4, HH23, LSH-B, LSH-beta |
| Background: | This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. |
| UniProt Protein Function: | LHB: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. Defects in LHB are a cause of hypogonadism LHB-related (HGON-LHB). Hypogonadism is characterized by infertility and pseudohermaphroditism. Belongs to the glycoprotein hormones subunit beta family. |
| UniProt Protein Details: | Protein type:Hormone; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: extracellular region Molecular Function:hormone activity; receptor binding Biological Process: progesterone biosynthetic process; cellular protein metabolic process; cell-cell signaling; male gonad development; peptide hormone processing; signal transduction Disease: Fertile Eunuch Syndrome |
| NCBI Summary: | This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P01229 |
| NCBI GenInfo Identifier: | 1170834 |
| NCBI Gene ID: | 3972 |
| NCBI Accession: | P01229.3 |
| UniProt Secondary Accession: | P01229,Q9UDI0, |
| UniProt Related Accession: | P01229 |
| Molecular Weight: | 141 |
| NCBI Full Name: | Lutropin subunit beta |
| NCBI Synonym Full Names: | luteinizing hormone beta polypeptide |
| NCBI Official Symbol: | LHB |
| NCBI Official Synonym Symbols: | CGB4; hLHB; LSH-B |
| NCBI Protein Information: | lutropin subunit beta; LSH-beta; lutropin beta chain; luteinizing hormone beta subunit; interstitial cell stimulating hormone, beta chain |
| UniProt Protein Name: | Lutropin subunit beta |
| UniProt Synonym Protein Names: | Luteinizing hormone subunit beta; LH-B; LSH-B; LSH-beta |
| Protein Family: | Lutropin/choriogonadotropin |
| UniProt Gene Name: | LHB |
| UniProt Entry Name: | LSHB_HUMAN |
 | Western blot analysis of extracts of K-562 cells, using LHB antibody (CAB3000) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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