The LGR5/GPR49 Monoclonal Antibody (CAB12327) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in a variety of research applications including immunohistochemistry and flow cytometry.The LGR5/GPR49 protein, also known as leucine-rich repeat-containing G protein-coupled receptor 5, is a marker for stem cells in various tissues, including the intestines and hair follicles. Its involvement in regulating cell proliferation and differentiation makes it a target of interest in studies of tissue regeneration and cancer biology.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse, Rat samples.
Product Name:
LGR5/GPR49 Monoclonal Antibody
SKU:
CAB12327
Size:
20μL, 100μL
Reactivity:
Mouse, Rat
Clone Number:
ARC0321
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method
Affinity purification
Gene ID
8549
RRID
AB_2861654
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using LGR5/GPR49 Rabbit mAb (CAB12327) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
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