Cell Biology Antibodies 13
Anti-LGR5/GPR49 Antibody (CAB12327)
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- SKU:
- CAB12327
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LGR5/GPR49 Antibody |
| Antibody SKU: | CAB12327 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human LGR5/GPR49 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse ovary, Mouse brain, Rat testis, Rat brain |
| Immunogen: | A synthesized peptide derived from human LGR5/GPR49 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8549 |
| Uniprot: | O75473 |
| Cellular Location: | |
| Calculated MW: | 100kDa |
| Observed MW: | 110KDa |
 | Western blot - LGR5/GPR49 Rabbit mAb (CAB12327) |
| Synonyms: | FEX, GPR49, GPR67, GRP49, HG38 |
| Background: | The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] |
| UniProt Protein Function: | LGR5: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of cycling, long-lived and multipotent adult stem cell populations. Target gene of Wnt signaling. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. Intestinal Lgr5+ stem cells give rise throughout life to proliferation of cells in crypts, which migrate along the crypt-villus axis, differentiating into five main cell types. Wnt signaling plays a crucial role in the proliferation and differentiation of these crypt epithelial cells. Two isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 12q21.1 Cellular Component: integral to plasma membrane; plasma membrane; trans-Golgi network membrane Molecular Function:G-protein coupled receptor activity; protein binding; transmembrane receptor activity |
| NCBI Summary: | The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] |
| UniProt Code: | O75473 |
| NCBI GenInfo Identifier: | 21542118 |
| NCBI Gene ID: | 8549 |
| NCBI Accession: | O75473.1 |
| UniProt Secondary Accession: | O75473,Q4VAM0, Q4VAM2, Q9UP75, D8MCT0, |
| UniProt Related Accession: | O75473 |
| Molecular Weight: | 100kDa |
| NCBI Full Name: | Leucine-rich repeat-containing G-protein coupled receptor 5 |
| NCBI Synonym Full Names: | leucine rich repeat containing G protein-coupled receptor 5 |
| NCBI Official Symbol: | LGR5 |
| NCBI Official Synonym Symbols: | FEX; HG38; GPR49; GPR67; GRP49 |
| NCBI Protein Information: | leucine-rich repeat-containing G-protein coupled receptor 5 |
| UniProt Protein Name: | Leucine-rich repeat-containing G-protein coupled receptor 5 |
| UniProt Synonym Protein Names: | G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38 |
| Protein Family: | Leucine-rich repeat-containing G-protein coupled receptor |
| UniProt Gene Name: | LGR5 |
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