Anti-LGI1 Antibody (CAB19230)

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SKU:
CAB19230
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
LGI1
Synonyms:
ADLTE
Synonyms:
ADPAEF
Synonyms:
ADPEAF
Synonyms:
EPITEMPIN
Synonyms:
EPT
Synonyms:
ETL1
Synonyms:
IB1099
Synonyms:
leucine rich glioma inactivated 1
Research Area:
Cell Biology

Description

Product Name:LGI1 Rabbit mAb
Product Code:CAB19230
Size:20uL, 50uL, 100uL
Synonyms:LGI1, ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099, leucine rich glioma inactivated 1
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human LGI1 .
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant protein of human LGI1 .
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9211
Uniprot:O95970
Cellular Location:Cell junction, Secreted, synapse
Calculated MW:64kDa
Observed MW:64KDa
UniProt Protein Function:LGI1: Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. Defects in LGI1 are the cause of epilepsy, familial temporal lobe, type 1 (ETL1). A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: extracellular space; extracellular region; synapse; cell junction

Molecular Function:protein binding; receptor binding

Biological Process: axon guidance; nervous system development; cell proliferation; positive regulation of cell growth; neurite development; protein homooligomerization; positive regulation of synaptic transmission

Disease: Epilepsy, Familial Temporal Lobe, 1

NCBI Summary:This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. [provided by RefSeq, Jul 2008]
UniProt Code:O95970
NCBI GenInfo Identifier:32469669
NCBI Gene ID:9211
NCBI Accession:O95970.1
UniProt Secondary Accession:O95970,Q5W001, Q5W002, Q8NI23, Q96LF5, A8K0Z1, B4E1S0
UniProt Related Accession:O95970
Molecular Weight:557
NCBI Full Name:Leucine-rich glioma-inactivated protein 1
NCBI Synonym Full Names:leucine-rich, glioma inactivated 1
NCBI Official Symbol:LGI1  
NCBI Official Synonym Symbols:EPT; ETL1; ADLTE; ADPAEF; ADPEAF; IB1099; EPITEMPIN  
NCBI Protein Information:leucine-rich glioma-inactivated protein 1; epitempin-1
UniProt Protein Name:Leucine-rich glioma-inactivated protein 1
UniProt Synonym Protein Names:Epitempin-1
Protein Family:Leucine-rich glioma-inactivated protein
UniProt Gene Name:LGI1  
UniProt Entry Name:LGI1_HUMAN
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