Signal Transduction Antibodies 2
Anti-LETM1 Antibody (CAB15685)
- SKU:
- CAB15685
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Antibody Name: | Anti-LETM1 Antibody |
Antibody SKU: | CAB15685 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human LETM1 (NP_036450.1). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | A-431, HeLa, Mouse heart, Mouse liver, Rat brain |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human LETM1 (NP_036450.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MASI LLRS CRGR APAR LPPP PRYT VPRG SPGD PAHL SCAS TLGL RNCL NVPF GCCT PIHP VYTS SRGD HLGC WALR PECL RIVS RAPW TSTS VGFV AVGP QCLP VRGW HSSR PVRD DSVV EKSL KSLK DKNK KLEE GGPV |
Gene ID: | 3954 |
Uniprot: | O95202 |
Cellular Location: | Mitochondrion inner membrane, Single-pass membrane protein |
Calculated MW: | 29kDa/33kDa/83kDa |
Observed MW: | 83kDa |
Synonyms: | LETM1 |
Background: | This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. |
UniProt Protein Function: | Function: Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization. Ref.7 |
UniProt Protein Details: | Subunit structure: Can form 2 complexes: a major (300 kDa) and a minor complex (500-600 kDa). Interacts with BCS1L. Ref.7 Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein Ref.5 Ref.6 Ref.7. Sequence similarities: Contains 1 EF-hand domain.Contains 1 LETM1 domain. Sequence caution: The sequence CAB63769.2 differs from that shown. Reason: Erroneous translation. Incomplete prediction of CDS at the C-terminus. |
NCBI Summary: | This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009] |
UniProt Code: | O95202 |
NCBI GenInfo Identifier: | 62510844 |
NCBI Gene ID: | 3954 |
NCBI Accession: | O95202.1 |
UniProt Secondary Accession: | O95202,Q9UF65, B4DED2, |
UniProt Related Accession: | O95202 |
Molecular Weight: | 83,354 Da |
NCBI Full Name: | LETM1 and EF-hand domain-containing protein 1, mitochondrial |
NCBI Synonym Full Names: | leucine zipper-EF-hand containing transmembrane protein 1 |
NCBI Official Symbol: | LETM1 |
NCBI Protein Information: | LETM1 and EF-hand domain-containing protein 1, mitochondrial; Mdm38 homolog; leucine zipper-EF-hand-containing transmembrane protein 1 |
UniProt Protein Name: | LETM1 and EF-hand domain-containing protein 1, mitochondrial |
UniProt Synonym Protein Names: | Leucine zipper-EF-hand-containing transmembrane protein 1 |
Protein Family: | LETM1 and EF-hand domain-containing protein |
UniProt Gene Name: | LETM1 |
UniProt Entry Name: | LETM1_HUMAN |
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