Cell Biology Antibodies 3
Anti-LARP7 Antibody (CAB13095)
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- SKU:
- CAB13095
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LARP7 Antibody |
| Antibody SKU: | CAB13095 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-380 of human LARP7 (NP_057732.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG, Jurkat, Mouse testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-380 of human LARP7 (NP_057732.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KSTG DPKG FAFV EFET KEQA AKAI EFLN NPPE EAPR KPGI FPKT VKNK PIPA LRVV EEKK KKKK KKGR MKKE DNIQ AKEE NMDT SNTS ISKM KRSR PTSE GSDI ESTE PQKQ CSKK KKKR DRVE ASSL PEVR TGKR KRSS SEDA ESLA PRSK VKKI IQKD IIKE ASEA SKEN RDIE ISTE EEKD TGDL KDSS LLKT KRKH KKKH KERH KMGE EVIP LRVL S |
| Gene ID: | 51574 |
| Uniprot: | Q4G0J3 |
| Cellular Location: | Nucleus, nucleoplasm |
| Calculated MW: | 24kDa/66kDa/67kDa |
| Observed MW: | 71kDa |
| Synonyms: | LARP7, ALAZS, HDCMA18P, PIP7S |
| Background: | This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | LARP7: Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 4q25 Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; ribonucleoprotein complex; nucleus Molecular Function:protein binding; nucleotide binding Biological Process: RNA processing Disease: Alazami Syndrome |
| NCBI Summary: | This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012] |
| UniProt Code: | Q4G0J3 |
| NCBI GenInfo Identifier: | 121945944 |
| NCBI Gene ID: | 51574 |
| NCBI Accession: | Q4G0J3.1 |
| UniProt Secondary Accession: | Q4G0J3,Q3B7A9, Q9P1S7, Q9Y3Z8, B2ZHN6, |
| UniProt Related Accession: | Q4G0J3 |
| Molecular Weight: | Calculated MW: 24kDa/66kDa/67kDaObserved MW:80kDa |
| NCBI Full Name: | La-related protein 7 |
| NCBI Synonym Full Names: | La ribonucleoprotein domain family, member 7 |
| NCBI Official Symbol: | LARP7 |
| NCBI Official Synonym Symbols: | ALAZS; PIP7S; HDCMA18P |
| NCBI Protein Information: | la-related protein 7; P-TEFb-interaction protein for 7SK stability |
| UniProt Protein Name: | La-related protein 7 |
| UniProt Synonym Protein Names: | La ribonucleoprotein domain family member 7; P-TEFb-interaction protein for 7SK stability; PIP7S |
| Protein Family: | La-related protein |
| UniProt Gene Name: | LARP7 |
| UniProt Entry Name: | LARP7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LARP7 antibody (CAB13095) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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