Metabolism Antibodies 1
Anti-KREMEN1 Antibody (CAB10507)
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- SKU:
- CAB10507
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-KREMEN1 Antibody |
| Antibody SKU: | CAB10507 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human KREMEN1 (NP_001034659.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, 22Rv1, A375, Mouse lung, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human KREMEN1 (NP_001034659.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YGEA ASTE CNSV CFGD HTQP CGGD GRII LFDT LVGA CGGN YSAM SSVV YSPD FPDT YATG RVCY WTIR VPGA SHIH FSFP LFDI RDSA DMVE LLDG YTHR VLAR FHGR SRPP LSFN VSLD FVIL YFFS DRIN QAQG FAVL YQAV KEEL PQER PAVN QTVA EVIT EQAN LSVS AARS SKVL YVIT TSPS HPPQ TVPG WTVY G |
| Gene ID: | 83999 |
| Uniprot: | Q96MU8 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 50kDa/51kDa/53kDa |
| Observed MW: | 70kDa |
| Synonyms: | KREMEN1, ECTD13, KREMEN, KRM1 |
| Background: | This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. |
| UniProt Protein Function: | KREMEN1: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 22q12.1 Cellular Component: membrane; integral to membrane Molecular Function:protein binding Biological Process: Wnt receptor signaling pathway; cell communication |
| NCBI Summary: | This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96MU8 |
| NCBI GenInfo Identifier: | 24041012 |
| NCBI Gene ID: | 83999 |
| NCBI Accession: | NP_114434 |
| UniProt Secondary Accession: | Q96MU8,Q5TIB9, Q6P3X6, Q9BY70, Q9UGS5, Q9UGU1, B0QY46 B0QY47, B1AJR5, |
| UniProt Related Accession: | Q96MU8 |
| Molecular Weight: | 54 kDa |
| NCBI Full Name: | kremen protein 1 isoform 2 |
| NCBI Synonym Full Names: | kringle containing transmembrane protein 1 |
| NCBI Official Symbol: | KREMEN1 |
| NCBI Official Synonym Symbols: | KRM1; KREMEN |
| NCBI Protein Information: | kremen protein 1; dickkopf receptor; kringle-coding gene marking the eye and the nose; kringle domain-containing transmembrane protein 1; kringle-containing protein marking the eye and the nose |
| UniProt Protein Name: | Kremen protein 1 |
| UniProt Synonym Protein Names: | Dickkopf receptor; Kringle domain-containing transmembrane protein 1; Kringle-containing protein marking the eye and the nose |
| Protein Family: | Kremen protein |
| UniProt Gene Name: | KREMEN1 |
| UniProt Entry Name: | KREM1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KREMEN1 antibody (CAB10507) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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