Epigenetics & Nuclear Signaling Antibodies 1

Anti-KLF17 Antibody (CAB13743)

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SKU:
CAB13743
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-KLF17 Antibody
Antibody SKU:CAB13743
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 210-389 of human KLF17 (NP_775755.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-87MG, HepG2, MCF7, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 210-389 of human KLF17 (NP_775755.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QMLP PQDA HDLG MPPA ESQS LLVL GSQD SLVS QPDS QEGP FLPE QPGP APQT VEKN SRPQ EGTG RRGS SEAR PYCC NYEN CGKA YTKR SHLV SHQR KHTG ERPY SCNW ESCS WSFF RSDE LRRH MRVH TRYR PYKC DQCS REFM RSDH LKQH QKTH RPGP SDPQ ANNN NGEQ DSPP AAGP
Gene ID:128209
Uniprot:Q5JT82
Cellular Location:Nucleus
Calculated MW:42kDa
Observed MW:43kDa
Synonyms:KLF17, ZNF393, Zfp393
Background:
UniProt Protein Function:KLF17: Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development. Belongs to the Sp1 C2H2-type zinc-finger protein family.
UniProt Protein Details:

Protein type:C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: nucleus

Molecular Function:metal ion binding; protein binding; transcription factor activity

Biological Process: gamete generation; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent

UniProt Code:Q5JT82
NCBI GenInfo Identifier:74762198
NCBI Gene ID:128209
NCBI Accession:Q5JT82.1
UniProt Secondary Accession:Q5JT82,Q86VQ7, Q8N805,
UniProt Related Accession:Q5JT82
Molecular Weight:42,577 Da
NCBI Full Name:Krueppel-like factor 17
NCBI Synonym Full Names:Kruppel-like factor 17
NCBI Official Symbol:KLF17  
NCBI Official Synonym Symbols:ZNF393; Zfp393  
NCBI Protein Information:Krueppel-like factor 17
UniProt Protein Name:Krueppel-like factor 17
UniProt Synonym Protein Names:Zinc finger protein 393
Protein Family:Krueppel-like factor
UniProt Gene Name:KLF17  
UniProt Entry Name:KLF17_HUMAN
Anti-KLF17 Antibody (CAB13743)Western blot analysis of extracts of various cell lines, using KLF17 antibody (CAB13743) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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