Cell Biology Antibodies 15

Anti-KLF11 Antibody (CAB18659)

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SKU:
CAB18659
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-KLF11 Antibody
Antibody SKU:CAB18659
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human KLF11.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:mouse thymus, mouse brain, rat lung
Immunogen:Recombinant protein of human KLF11.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8462
Uniprot:O14901
Cellular Location:
Calculated MW:
Observed MW:55kDa
Anti-KLF11 Antibody (CAB18659)Western blot - KLF11 Rabbit pAb (CAB18659)
Synonyms:
Background:
UniProt Protein Function:TIEG2: Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. Defects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 2p25

Molecular Function:protein binding; transcription factor activity

Biological Process: G1/S-specific transcription in mitotic cell cycle; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; transcription from RNA polymerase II promoter

Disease: Maturity-onset Diabetes Of The Young, Type 7

NCBI Summary:The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
UniProt Code:O14901
NCBI GenInfo Identifier:11387048
NCBI Gene ID:8462
NCBI Accession:O14901.2
UniProt Secondary Accession:O14901,Q9EPF4, B4DZE7,
UniProt Related Accession:O14901
Molecular Weight:53,329 Da
NCBI Full Name:Krueppel-like factor 11
NCBI Synonym Full Names:Kruppel like factor 11
NCBI Official Symbol:KLF11  
NCBI Official Synonym Symbols:FKLF; FKLF1; MODY7; TIEG2; Tieg3  
NCBI Protein Information:Krueppel-like factor 11
UniProt Protein Name:Krueppel-like factor 11
UniProt Synonym Protein Names:Transforming growth factor-beta-inducible early growth response protein 2; TGFB-inducible early growth response protein 2; TIEG-2
Protein Family:Krueppel-like factor
UniProt Gene Name:KLF11  
UniProt Entry Name:KLF11_HUMAN
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