Immunology Antibodies 2

Kinesin light chain 1 (KLC1) Rabbit Polyclonal Antibody (CAB5552)

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SKU:
CAB5552
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
Reactivity:
Human, Mouse, Rat
Synonyms:
KLC, KNS2, KNS2A, Kinesin light chain 1 (KLC1)
Research Use:
Immunology
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Description

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Kinesin light chain 1 (KLC1) Antibody (CAB5552)

The Kinesin light chain 1 (KLC1) Antibody (CAB5552) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications. By binding to the KLC1 protein, this antibody enables precise detection and analysis in various cell types, facilitating investigations in cell biology and neurology.KLC1 is a key component in the transport machinery of cells, playing a crucial role in the movement of organelles, proteins, and other cargo along microtubules.

This antibody is validated for use in WB, IHC-P, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:Kinesin light chain 1 (KLC1) Antibody
SKU:CAB5552
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:LALV YRDQ NKYK DAAN LLND ALAI REKT LGKD HPAV AATL NNLA VLYG KRGK YKEA EPLC KRAL EIRE KVLG KDHP DVAK QLNN LALL CQNQ GKYE EVEY YYQR ALEI YQTK LGPD DPNV AKTK NNLA SCYL KQGK FKQA ETLY KEIL TRAH EREF GSVD DENK PIWM HAEE REEC KGKQ KDGT SFGE YGGW YKAC KVDS PTVT TTLK NLGA LYRR QGKF EAAE TLEE AAMR SRKQ GLDN VHKQ RVAE VLND PENM EKRR SRES LNVD VVKY ESGP DGGE EVSM SVEW NGMR KMKL GLVN
Tested Applications:WB IHC-P ELISA
Recommended Dilution:
WB1:500 - 1:2000
IHC-P1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:KLC, KNS2, KNS2A, Kinesin light chain 1 (KLC1)
Positive Sample:SW480, 22Rv1, BT-474, MCF7, Mouse brain
Cellular Localization:Cell Projection, Cytoplasm, Cytoplasmic Vesicle, Cytoskeleton, Growth Cone.
Calculated MW:65kDa
Observed MW:60-75kDa

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined.

Purification MethodAffinity purification
Gene ID3831
RRIDAB_2766332
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using Kinesin light chain 1 (KLC1) Rabbit pAb (CAB5552) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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