Anti-Kinesin light chain 1 (KLC1) Antibody (CAB19249)

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SKU:
CAB19249
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
KLC1
Synonyms:
KLC
Synonyms:
KNS2
Synonyms:
KNS2A
Synonyms:
kinesin light chain 1
Research Area:
Immunology

Description

Product Name:Kinesin light chain 1 (KLC1) Rabbit mAb
Product Code:CAB19249
Size:20uL, 50uL, 100uL
Synonyms:KLC1, KLC, KNS2, KNS2A, kinesin light chain 1
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human Kinesin light chain 1 (Kinesin light chain 1 (KLC1)).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, MCF7, U-87MG, Mouse brain, Rat brain
Immunogen:Recombinant protein of human Kinesin light chain 1 (Kinesin light chain 1 (KLC1)).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3831
Uniprot:Q07866
Cellular Location:Cell projection, Cytoplasm, Cytoplasmic vesicle, cytoskeleton, growth cone
Calculated MW:65kDa
Observed MW:65KDa/75KDa
UniProt Protein Function:KLC1: a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
UniProt Protein Details:

Protein type:Motor; Microtubule-binding

Chromosomal Location of Human Ortholog: 14q32.3

Cellular Component: ciliary rootlet; kinesin complex; microtubule; growth cone; membrane; cell soma; axon; cytoplasmic membrane-bound vesicle; cytosol

Molecular Function:tubulin binding; protein binding; motor activity; microtubule motor activity

Biological Process: intracellular protein transport; viral reproduction; metabolic process; axon cargo transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; microtubule-based movement

NCBI Summary:Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q07866
NCBI GenInfo Identifier:223590110
NCBI Gene ID:3831
NCBI Accession:Q07866.2
UniProt Secondary Accession:Q07866,Q7RTM2, Q7RTM3, Q7RTM5, Q7RTP9, Q7RTQ3, Q7RTQ5 Q7RTQ6, Q86SF5, Q86TF5, A6NF62, F8VTM4,
UniProt Related Accession:Q07866
Molecular Weight:573
NCBI Full Name:Kinesin light chain 1
NCBI Synonym Full Names:kinesin light chain 1
NCBI Official Symbol:KLC1  
NCBI Official Synonym Symbols:KLC; KNS2; KNS2A  
NCBI Protein Information:kinesin light chain 1; kinesin 2 60/70kDa; medulloblastoma antigen MU-MB-2.50
UniProt Protein Name:Kinesin light chain 1
Protein Family:Kinesin
UniProt Gene Name:KLC1  
UniProt Entry Name:KLC1_HUMAN
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