Signal Transduction Antibodies 1

Anti-KIF5C Antibody (CAB13801)

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SKU:
CAB13801
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-KIF5C Antibody
Antibody SKU:CAB13801
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 510-590 of human KIF5C (NP_004513.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HT-29, OVCAR3
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 510-590 of human KIF5C (NP_004513.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RANE QLTD ELAQ KTTT LTTT QREL SQLQ ELSN HQKK RATE ILNL LLKD LGEI GGII GTND VKTL ADVN GVIE EEFT MARL Y
Gene ID:3800
Uniprot:O60282
Cellular Location:Cytoplasm, cytoskeleton
Calculated MW:83kDa/109kDa
Observed MW:109kDa
Synonyms:KIF5C, CDCBM2, KINN, NKHC, NKHC-2, NKHC2
Background:The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene.
UniProt Protein Function:KIF5C: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Belongs to the kinesin-like protein family. Kinesin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 2q23.1

Cellular Component: kinesin complex

Molecular Function:microtubule motor activity; plus-end-directed microtubule motor activity; protein binding

Biological Process: axon guidance; cytoskeleton-dependent intracellular transport; microtubule-based movement; mRNA transport; organelle organization and biogenesis; protein localization

Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 2

NCBI Summary:The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015]
UniProt Code:O60282
NCBI GenInfo Identifier:13124319
NCBI Gene ID:3800
NCBI Accession:O60282.1
UniProt Secondary Accession:O60282,O95079, Q2YDC5,
UniProt Related Accession:O60282
Molecular Weight:83,178 Da
NCBI Full Name:Kinesin heavy chain isoform 5C
NCBI Synonym Full Names:kinesin family member 5C
NCBI Official Symbol:KIF5C  
NCBI Official Synonym Symbols:KINN; NKHC; NKHC2; CDCBM2; NKHC-2  
NCBI Protein Information:kinesin heavy chain isoform 5C
UniProt Protein Name:Kinesin heavy chain isoform 5C
UniProt Synonym Protein Names:Kinesin heavy chain neuron-specific 2
Protein Family:Kinesin
UniProt Gene Name:KIF5C  
UniProt Entry Name:KIF5C_HUMAN
Anti-KIF5C Antibody (CAB13801)Western blot analysis of extracts of various cell lines, using KIF5C antibody (CAB13801) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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