Signal Transduction Antibodies 1

Anti-KIF16B Antibody (CAB10314)

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SKU:
CAB10314
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-KIF16B Antibody
Antibody SKU:CAB10314
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human KIF16B (NP_078980.3).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human KIF16B (NP_078980.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASV KVAV RVRP MNRR EKDL EAKF IIQM EKSK TTIT NLKI PEGG TGDS GRER TKTF TYDF SFYS ADTK SPDY VSQE MVFK TLGT DVVK SAFE GYNA CVFA YGQT GSGK SYTM MGNS GDSG LIPR ICEG LFSR INET TRWD EASF RTEV SYLE IYNE RVRD LLRR KSSK TFNL RVRE HPKE GPYV EDLS KHLV QNYG DVEE LMDA GNIN RT
Gene ID:55614
Uniprot:Q96L93
Cellular Location:Cytoplasm, Early endosome membrane, cytoskeleton
Calculated MW:132kDa/147kDa/148kDa/152kDa/159kDa
Observed MW:160kDa
Synonyms:KIF16B, C20orf23, KISC20ORF, SNX23
Background:The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:KIF16B: Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. Belongs to the kinesin-like protein family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 20p12.1

Cellular Component: early endosome; endosome; kinesin complex

Molecular Function:phosphatidylinositol 3-phosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; plus-end-directed microtubule motor activity

Biological Process: early endosome to late endosome transport; endoderm development; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; formation of primary germ layer; Golgi to endosome transport; microtubule-based movement; receptor catabolic process; regulation of receptor recycling

NCBI Summary:The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
UniProt Code:Q96L93
NCBI GenInfo Identifier:50403793
NCBI Gene ID:55614
NCBI Accession:Q96L93.2
UniProt Secondary Accession:Q96L93,Q2TBF5, Q5HYC0, Q5HYK1, A6NKJ9, A7E2A8, B1AKG3 B1AKT7, C9JDN5, C9JI52, C9JSM8, C9JWJ7,
UniProt Related Accession:Q96L93
Molecular Weight:152kDa
NCBI Full Name:Kinesin-like protein KIF16B
NCBI Synonym Full Names:kinesin family member 16B
NCBI Official Symbol:KIF16B  
NCBI Official Synonym Symbols:SNX23; C20orf23; KISC20ORF  
NCBI Protein Information:kinesin-like protein KIF16B
UniProt Protein Name:Kinesin-like protein KIF16B
UniProt Synonym Protein Names:Sorting nexin-23
Protein Family:Kinesin-like protein
UniProt Gene Name:KIF16B  
Anti-KIF16B Antibody (CAB10314)Western blot analysis of extracts of 293T cells, using KIF16B antibody (CAB10314) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
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