Signal Transduction Antibodies 1

Anti-KCNV2 Antibody (CAB10340)

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SKU:
CAB10340
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-KCNV2 Antibody
Antibody SKU:CAB10340
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 177-261 of human KCNV2 (NP_598004.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 177-261 of human KCNV2 (NP_598004.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CPRR FLEE LGYW GVRL KYTP RCCR ICFE ERRD ELSE RLKI QHEL RAQA QVEE AEEL FRDM RFYG PQRR RLWN LMEK PFSS VAAK A
Gene ID:169522
Uniprot:Q8TDN2
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:62kDa
Observed MW:Refer to figures
Synonyms:KCNV2, KV11.1, Kv8.2, RCD3B
Background:Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues.
UniProt Protein Function:Kv8.2: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B); also called cone dystrophy with night blindness and supernormal rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy. Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p24.2

Cellular Component: integral to membrane; plasma membrane

Molecular Function:delayed rectifier potassium channel activity

Disease: Retinal Cone Dystrophy 3b

NCBI Summary:Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. [provided by RefSeq, Jul 2008]
UniProt Code:Q8TDN2
NCBI GenInfo Identifier:26006804
NCBI Gene ID:169522
NCBI Accession:Q8TDN2.1
UniProt Secondary Accession:Q8TDN2,Q5T6X0,
UniProt Related Accession:Q8TDN2
Molecular Weight:62,459 Da
NCBI Full Name:Potassium voltage-gated channel subfamily V member 2
NCBI Synonym Full Names:potassium voltage-gated channel modifier subfamily V member 2
NCBI Official Symbol:KCNV2  
NCBI Official Synonym Symbols:Kv8.2; RCD3B; KV11.1  
NCBI Protein Information:potassium voltage-gated channel subfamily V member 2
UniProt Protein Name:Potassium voltage-gated channel subfamily V member 2
UniProt Synonym Protein Names:Voltage-gated potassium channel subunit Kv8.2
Protein Family:Potassium voltage-gated channel subfamily
UniProt Gene Name:KCNV2  
UniProt Entry Name:KCNV2_HUMAN
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