Antibody Name:	Anti-KCNQ1 Antibody
Antibody SKU:	CAB2174
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 250-549 of human KCNQ1 (NP_861463.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	293T, Mouse pancreas, Rat lung, Rat kidney, Rat heart

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 250-549 of human KCNQ1 (NP_861463.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	TAWR CYAA ENPD SSTW KIYI RKAP RSHT LLSP SPKP KKSV VVKK KKFK LDKD NGVT PGEK MLTV PHIT CDPP EERR LDHF SVDG YDSS VRKS PTLL EVSM PHFM RTNS FAED LDLE GETL LTPI THIS QLRE HHRA TIKV IRRM QYFV AKKK FQQA RKPY DVRD VIEQ YSQG HLNL MVRI KELQ RRLD QSIG KPSL FISV SEKS KDRG SNTI GARL NRVE DKVT QLDQ RLAL ITDM LHQL LSLH GGST PGSG GPPR EGGA HITQ PCGS GGSV DPEL FLPS NTLP TYEQ LTVP RRGP DEGS
Gene ID:	3784
Uniprot:	P51787
Cellular Location:	Cell membrane, Cytoplasmic vesicle membrane, Multi-pass membrane protein
Calculated MW:	61kDa/74kDa
Observed MW:	70KDa/75KDa

Synonyms:

KCNQ1, ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, KVLQT1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, WRS

Background:

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.

UniProt Protein Function:	Kv7.1: a voltage-gated potassium channel protein required for the repolarization phase of the cardiac action potential. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea. Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries. Three alternatively spliced isoforms have been described.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: voltage-gated potassium channel complex; cytoplasmic vesicle membrane; lysosome; basolateral plasma membrane; late endosome; early endosome; plasma membrane Molecular Function:calmodulin binding; protein binding; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; protein phosphatase 1 binding Biological Process: synaptic transmission; genetic imprinting; sensory perception of sound; positive regulation of heart rate; gene silencing; regulation of heart contraction; cardiac muscle contraction Disease: Jervell And Lange-nielsen Syndrome 1; Beckwith-wiedemann Syndrome; Atrial Fibrillation, Familial, 3; Short Qt Syndrome 2; Long Qt Syndrome 1
NCBI Summary:	This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
UniProt Code:	P51787
NCBI GenInfo Identifier:	6166005
NCBI Gene ID:	3784
NCBI Accession:	P51787.3
UniProt Secondary Accession:	P51787,O00347, O60607, O94787, Q14D14, Q7Z6G9, Q92960 Q9UMN8, Q9UMN9,
UniProt Related Accession:	P51787
Molecular Weight:	61,474 Da
NCBI Full Name:	Potassium voltage-gated channel subfamily KQT member 1
NCBI Synonym Full Names:	potassium voltage-gated channel, KQT-like subfamily, member 1
NCBI Official Symbol:	KCNQ1
NCBI Official Synonym Symbols:	LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1
NCBI Protein Information:	potassium voltage-gated channel subfamily KQT member 1; slow delayed rectifier channel subunit; voltage-gated potassium channel subunit Kv7.1; kidney and cardiac voltage dependend K+ channel; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
UniProt Protein Name:	Potassium voltage-gated channel subfamily KQT member 1
UniProt Synonym Protein Names:	IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1
Protein Family:	Potassium voltage-gated channel subfamily
UniProt Gene Name:	KCNQ1
UniProt Entry Name:	KCNQ1_HUMAN

	Western blot analysis of extracts of various cell lines, using KCNQ1 Rabbit pAb (CAB2174) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
	Western blot analysis of extracts of various cell lines, using KCNQ1 Rabbit pAb (CAB2174) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.