Signal Transduction Antibodies 1

Anti-KCNK4 Antibody (CAB12217)

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SKU:
CAB12217
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-KCNK4 Antibody
Antibody SKU:CAB12217
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-90 of human KCNK4 (NP_201567.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-90 of human KCNK4 (NP_201567.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RALE QPHE QQAQ RELG EVRE KFLR AHPC VSDQ ELGL LIKE VADA LGGG ADPE TNST SNSS HSAW DL
Gene ID:50801
Uniprot:Q9NYG8
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:42kDa/45kDa
Observed MW:58kDa
Synonyms:KCNK4, K2p4.1, TRAAK, TRAAK1
Background:This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802.
UniProt Protein Function:KCNK4: Voltage insensitive, instantaneous, outwardly rectifying potassium channel. Outward rectification is reversed at high external K(+) concentrations. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: plasma membrane; integral to membrane

Molecular Function:potassium channel activity; voltage-gated ion channel activity

Biological Process: synaptic transmission; potassium ion transport

NCBI Summary:Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NYG8
NCBI GenInfo Identifier:13124080
NCBI Gene ID:50801
NCBI Accession:Q9NYG8.2
UniProt Secondary Accession:Q9NYG8,Q96T94, B5TJL1,
UniProt Related Accession:Q9NYG8
Molecular Weight:42,704 Da
NCBI Full Name:Potassium channel subfamily K member 4
NCBI Synonym Full Names:potassium channel, subfamily K, member 4
NCBI Official Symbol:KCNK4  
NCBI Official Synonym Symbols:TRAAK; K2p4.1; TRAAK1  
NCBI Protein Information:potassium channel subfamily K member 4; K2P4.1 potassium channel; two pore K+ channel KT4.1; two pore K(+) channel KT4.1; two pore potassium channel KT4.1; TWIK-related arachidonic acid-stimulated potassium channel protein
UniProt Protein Name:Potassium channel subfamily K member 4
UniProt Synonym Protein Names:TWIK-related arachidonic acid-stimulated potassium channel protein; TRAAK; Two pore potassium channel KT4.1
Protein Family:Potassium channel subfamily
UniProt Gene Name:KCNK4  
UniProt Entry Name:KCNK4_HUMAN
Anti-KCNK4 Antibody (CAB12217)Western blot analysis of extracts of HepG2 cells, using KCNK4 antibody (CAB12217) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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