Antibody Name:	Anti-KCNE2 Antibody
Antibody SKU:	CAB9859
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNE2 (NP_751951.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	U-251MG

Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNE2 (NP_751951.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MSTL SNFT QTLE DVFR RIFI TYMD NWRQ NTTA EQEA LQAK VDAE NFYY VILY LMVM IGMF SFII VAIL VSTV KSKR REHS NDPY HQYI VEDW QEKY KSQI
Gene ID:	9992
Uniprot:	Q9Y6J6
Cellular Location:	Cell membrane, Single-pass type I membrane protein
Calculated MW:	14kDa
Observed MW:	15kDa

Synonyms:

KCNE2, ATFB4, LQT5, LQT6, MIRP1

Background:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia.

UniProt Protein Function:	KCNE2: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current. Defects in KCNE2 are the cause of long QT syndrome type 6 (LQT6). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. KCNE2 mutants form channels that open slowly and close rapidly, thereby diminishing potassium currents. Defects in KCNE2 are the cause of familial atrial fibrillation type 4 (ATFB4). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the potassium channel KCNE family.
UniProt Protein Details:	Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 21q22.12 Cellular Component: cell surface; lysosome; plasma membrane; voltage-gated potassium channel complex Molecular Function:delayed rectifier potassium channel activity; inward rectifier potassium channel activity; potassium channel regulator activity; protein binding Biological Process: potassium ion import Disease: Atrial Fibrillation, Familial, 4; Long Qt Syndrome 6
NCBI Summary:	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9Y6J6
NCBI GenInfo Identifier:	6685661
NCBI Gene ID:	9992
NCBI Accession:	Q9Y6J6.1
UniProt Secondary Accession:	Q9Y6J6,Q52LJ5, A5H1P3, D3DSF8,
UniProt Related Accession:	Q9Y6J6
Molecular Weight:	14,472 Da
NCBI Full Name:	Potassium voltage-gated channel subfamily E member 2
NCBI Synonym Full Names:	potassium voltage-gated channel subfamily E regulatory subunit 2
NCBI Official Symbol:	KCNE2
NCBI Official Synonym Symbols:	LQT5; LQT6; ATFB4; MIRP1
NCBI Protein Information:	potassium voltage-gated channel subfamily E member 2
UniProt Protein Name:	Potassium voltage-gated channel subfamily E member 2
UniProt Synonym Protein Names:	MinK-related peptide 1; Minimum potassium ion channel-related peptide 1; Potassium channel subunit beta MiRP1
Protein Family:	Potassium voltage-gated channel subfamily
UniProt Gene Name:	KCNE2
UniProt Entry Name:	KCNE2_HUMAN