Signal Transduction Antibodies 1
Anti-KCNE1 Antibody (CAB14009)
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- SKU:
- CAB14009
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-KCNE1 Antibody |
| Antibody SKU: | CAB14009 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human KCNE1 (NP_001121142.1). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human KCNE1 (NP_001121142.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MILS NTTA VTPF LTKL WQET VQQG GNMS GLAR RSPR SSDG KLEA LYVL MVLG FFGF FTLG IMLS YIRS KKLE HSND PFNV YIES DAWQ EKDK AYVQ ARVL ESYR S |
| Gene ID: | 3753 |
| Uniprot: | P15382 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 14kDa |
| Observed MW: |
| Synonyms: | KCNE1, ISK, JLNS, JLNS2, LQT2/5, LQT5, MinK |
| Background: | The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. |
| UniProt Protein Function: | KCNE1: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Associates with KCNQ1/KVLQT1 and KCNH2/HERG. Expressed in heart, lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells. Belongs to the potassium channel KCNE family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, potassium Chromosomal Location of Human Ortholog: 21q22.12 Cellular Component: voltage-gated potassium channel complex; cell surface; lysosome; apical plasma membrane; plasma membrane; Z disc Molecular Function:voltage-gated potassium channel activity; protein binding; potassium channel regulator activity; telethonin binding; delayed rectifier potassium channel activity Biological Process: protein amino acid O-linked glycosylation; sensory perception of sound; protein amino acid N-linked glycosylation Disease: Jervell And Lange-nielsen Syndrome 2; Long Qt Syndrome 5 |
| NCBI Summary: | The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P15382 |
| NCBI GenInfo Identifier: | 116416 |
| NCBI Gene ID: | 3753 |
| NCBI Accession: | P15382.1 |
| UniProt Related Accession: | P15382 |
| Molecular Weight: | |
| NCBI Full Name: | Potassium voltage-gated channel subfamily E member 1 |
| NCBI Synonym Full Names: | potassium voltage-gated channel subfamily E regulatory subunit 1 |
| NCBI Official Symbol: | KCNE1 |
| NCBI Official Synonym Symbols: | ISK; JLNS; LQT5; MinK; JLNS2; LQT2/5 |
| NCBI Protein Information: | potassium voltage-gated channel subfamily E member 1 |
| UniProt Protein Name: | Potassium voltage-gated channel subfamily E member 1 |
| UniProt Synonym Protein Names: | Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Minimal potassium channel |
| Protein Family: | Potassium voltage-gated channel subfamily |
| UniProt Gene Name: | KCNE1 |
| UniProt Entry Name: | KCNE1_HUMAN |
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