Signal Transduction Antibodies 2
Anti-KCND1 Antibody (CAB15683)
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- SKU:
- CAB15683
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-KCND1 Antibody |
| Antibody SKU: | CAB15683 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 488-647 of human KCND1 (NP_004970.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, 293T, BxPC-3, Mouse brain, Mouse pancreas, Mouse heart, Rat brain, Rat pancreas, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 488-647 of human KCND1 (NP_004970.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TTCH EFTD ELTF SEAL GAVS PGGR TSRS TSVS SQPV GPGS LLSS CCPR RAKR RAIR LANS TASV SRGS MQEL DMLA GLRR SHAP QSRS SLNA KPHD SLDL NCDS RDFV AAII SIPT PPAN TPDE SQPS SPGG GGRA GSTL RNSS LGTP CLFP ETVK ISSL |
| Gene ID: | 3750 |
| Uniprot: | Q9NSA2 |
| Cellular Location: | Cell projection, Membrane, Multi-pass membrane protein, dendrite |
| Calculated MW: | 28kDa/71kDa |
| Observed MW: | 71kDa |
| Synonyms: | KCND1, KV4.1 |
| Background: | This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. |
| UniProt Protein Function: | KCND1: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: Xp11.23 Cellular Component: integral to membrane; plasma membrane Molecular Function:A-type (transient outward) potassium channel activity; delayed rectifier potassium channel activity |
| NCBI Summary: | This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q9NSA2 |
| NCBI GenInfo Identifier: | 38258256 |
| NCBI Gene ID: | 3750 |
| NCBI Accession: | Q9NSA2.2 |
| UniProt Secondary Accession: | Q9NSA2,O75671, A6NEF1, B2RCG0, |
| UniProt Related Accession: | Q9NSA2 |
| Molecular Weight: | 28,860 Da |
| NCBI Full Name: | Potassium voltage-gated channel subfamily D member 1 |
| NCBI Synonym Full Names: | potassium voltage-gated channel subfamily D member 1 |
| NCBI Official Symbol: | KCND1 |
| NCBI Official Synonym Symbols: | KV4.1 |
| NCBI Protein Information: | potassium voltage-gated channel subfamily D member 1 |
| UniProt Protein Name: | Potassium voltage-gated channel subfamily D member 1 |
| UniProt Synonym Protein Names: | Voltage-gated potassium channel subunit Kv4.1 |
| Protein Family: | Potassium voltage-gated channel subfamily |
| UniProt Gene Name: | KCND1 |
| UniProt Entry Name: | KCND1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KCND1 antibody (CAB15683) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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