Name: Anti-KCNC4 Antibody (CAB15682)
Brand: Signal Transduction Antibodies 2
SKU: CAB15682
Availability: OutOfStock

Antibody Name:	Anti-KCNC4 Antibody
Antibody SKU:	CAB15682
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 490-538 of human KCNC4 (NP_004969.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	U-87MG, Mouse brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 490-538 of human KCNC4 (NP_004969.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	KKRK KHVP RPAQ LESP MYCK SEET SPRD STCS DTSP PARE EGMI ERKR A
Gene ID:	3749
Uniprot:	Q03721
Cellular Location:	Membrane, Multi-pass membrane protein
Calculated MW:	64kDa/68kDa/69kDa
Observed MW:	110kDa

Synonyms:

KCNC4, C1orf30, HKSHIIIC, KSHIIIC, KV3.4

Background:

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene.

UniProt Protein Function:	Kv3.4: This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p21 Cellular Component: plasma membrane Molecular Function:delayed rectifier potassium channel activity; potassium channel activity; voltage-gated potassium channel activity Biological Process: potassium ion transport; synaptic transmission
NCBI Summary:	The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
UniProt Code:	Q03721
NCBI GenInfo Identifier:	66774206
NCBI Gene ID:	3749
NCBI Accession:	Q03721.2
UniProt Secondary Accession:	Q03721,Q3MIM4, Q5TBI6,
UniProt Related Accession:	Q03721
Molecular Weight:	68,824 Da
NCBI Full Name:	Potassium voltage-gated channel subfamily C member 4
NCBI Synonym Full Names:	potassium voltage-gated channel subfamily C member 4
NCBI Official Symbol:	KCNC4
NCBI Official Synonym Symbols:	KV3.4; C1orf30; KSHIIIC; HKSHIIIC
NCBI Protein Information:	potassium voltage-gated channel subfamily C member 4
UniProt Protein Name:	Potassium voltage-gated channel subfamily C member 4
UniProt Synonym Protein Names:	KSHIIIC; Voltage-gated potassium channel subunit Kv3.4
Protein Family:	Potassium voltage-gated channel subfamily
UniProt Gene Name:	KCNC4
UniProt Entry Name:	KCNC4_HUMAN

Western blot analysis of extracts of various cell lines, using KCNC4 antibody (CAB15682) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.

Antibodies

Phospho-KCNC4 (S15) Antibody (PACO05963)

KCNC4 Antibody (PACO06608)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)