Developmental Biology

Anti-KAT5 Antibody (CAB13259)

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SKU:
CAB13259
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-KAT5 Antibody
Antibody SKU:CAB13259
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 260-513 of human KAT5 (NP_006379.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:20 - 1:50
Reactivity:Human
Positive Samples:HL-60, MCF7
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 260-513 of human KAT5 (NP_006379.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LYLC EFCL KYGR SLKC LQRH LTKC DLRH PPGN EIYR KGTI SFFE IDGR KNKS YSQN LCLL AKCF LDHK TLYY DTDP FLFY VMTE YDCK GFHI VGYF SKEK ESTE DYNV ACIL TLPP YQRR GYGK LLIE FSYE LSKV EGKT GTPE KPLS DLGL LSYR SYWS QTIL EILM GLKS ESGE RPQI TINE ISEI TSIK KEDV ISTL QYLN LINY YKGQ YILT LSED IVDG HERA MLKR LLRI DSKC LHFT PKDW SKRG KW
Gene ID:10524
Uniprot:Q92993
Cellular Location:Cytoplasm, Nucleus, nucleolus, perinuclear region
Calculated MW:53kDa/56kDa/58kDa/61kDa
Observed MW:56kDa
Synonyms:KAT5, ESA1, HTATIP, HTATIP1, PLIP, TIP, TIP60, ZC2HC5, cPLA2
Background:The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.
UniProt Protein Function:Tip60: a histone acetyl transferase (HAT) of the MYST family. Originally isolated as an HIV-1 TAT-interactive protein. Plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating nuclear proteins. Plays a role in DNA repair and apoptosis. Three splice variants have been described.
UniProt Protein Details:

Protein type:Acetyltransferase; Nucleolus; Nuclear receptor co-regulator; EC 2.3.1.48

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: NuA4 histone acetyltransferase complex; nucleolus; nucleoplasm; nucleus

Molecular Function:acetyltransferase activity; histone acetyltransferase activity; protein binding; transcription coactivator activity

Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA double-strand break processing; DNA replication; DNA synthesis during DNA repair; double-strand break repair; double-strand break repair via nonhomologous end joining; histone acetylation; negative regulation of interleukin-2 production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; response to ionizing radiation; strand displacement

NCBI Summary:The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Code:Q92993
NCBI GenInfo Identifier:30923328
NCBI Gene ID:10524
NCBI Accession:Q92993.2
UniProt Secondary Accession:Q92993,O95624, Q13430, Q17RW5, Q561W3, Q6GSE8, Q9BWK7 B4E3C7, C9JL99,
UniProt Related Accession:Q92993
Molecular Weight:56,292 Da
NCBI Full Name:Histone acetyltransferase KAT5
NCBI Synonym Full Names:lysine acetyltransferase 5
NCBI Official Symbol:KAT5  
NCBI Official Synonym Symbols:TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; ZC2HC5; HTATIP1  
NCBI Protein Information:histone acetyltransferase KAT5
UniProt Protein Name:Histone acetyltransferase KAT5
UniProt Synonym Protein Names:60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting protein
Protein Family:3-ketoacyl-CoA thiolase
UniProt Gene Name:KAT5  
UniProt Entry Name:KAT5_HUMAN
Anti-KAT5 Antibody (CAB13259)Western blot analysis of extracts of various cell lines, using KAT5 antibody (CAB13259) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-KAT5 Antibody (CAB13259)Immunofluorescence analysis of A549 cells using KAT5 antibody (CAB13259). Blue: DAPI for nuclear staining.
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