Cell Death Antibodies 1
Anti-JTB Antibody (CAB10427)
- SKU:
- CAB10427
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-JTB Antibody |
| Antibody SKU: | CAB10427 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-105 of human JTB (NP_006685.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | MCF7, NCI-H460, A375, Rat spleen, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-105 of human JTB (NP_006685.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EAPV QEEK LSAS TSNL PCWL VEEF VVAE ECSP CSNF RAKT TPEC GPTG YVEK ITCS SSKR NEFK SCRS ALME QRL |
| Gene ID: | 10899 |
| Uniprot: | O76095 |
| Cellular Location: | Cytoplasm, Membrane, Mitochondrion, Single-pass type I membrane protein, centrosome, cytoskeleton, microtubule organizing center, spindle |
| Calculated MW: | 13kDa/16kDa |
| Observed MW: | 16kDa |
| Synonyms: | JTB, HJTB, HSPC222, PAR, hJT |
| Background: |
| UniProt Protein Function: | JTB: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. Belongs to the JTB family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: centrosome; cytoplasm; integral to plasma membrane; membrane; midbody; spindle Molecular Function:protein kinase binding Biological Process: cytokinesis; mitotic cell cycle; positive regulation of protein kinase activity |
| UniProt Code: | O76095 |
| NCBI GenInfo Identifier: | 6016408 |
| NCBI Gene ID: | 10899 |
| NCBI Accession: | O76095.1 |
| UniProt Secondary Accession: | O76095,O95442, Q6IB19, Q9P0Q4, |
| UniProt Related Accession: | O76095 |
| Molecular Weight: | 16kDa |
| NCBI Full Name: | Protein JTB |
| NCBI Synonym Full Names: | jumping translocation breakpoint |
| NCBI Official Symbol: | JTB |
| NCBI Official Synonym Symbols: | PAR; hJT; HJTB; HSPC222 |
| NCBI Protein Information: | protein JTB |
| UniProt Protein Name: | Protein JTB |
| UniProt Synonym Protein Names: | Jumping translocation breakpoint protein; Prostate androgen-regulated protein; PAR protein |
| Protein Family: | Protein |
| UniProt Gene Name: | JTB |
 | Western blot analysis of extracts of various cell lines, using JTB antibody (CAB10427) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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