Cell Biology Antibodies 13

Anti-ITPKA Antibody (CAB17503)

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SKU:
CAB17503
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ITPKA Antibody
Antibody SKU:CAB17503
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 141-461 of human ITPKA (NP_002211.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 141-461 of human ITPKA (NP_002211.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLSD SESR SRGN VQLE AGED VGQK NHWQ KIRT MVNL PVIS PFKK RYAW VQLA GHTG SFKA AGTS GLIL KRCS EPER YCLA RLMA DALR GCVP AFHG VVER DGES YLQL QDLL DGFD GPCV LDCK MGVR TYLE EELT KARE RPKL RKDM YKKM LAVD PEAP TEEE HAQR AVTK PRYM QWRE GISS STTL GFRI EGIK KADG SCST DFKT TRSR EQVL RVFE EFVQ GDEE VLRR YLNR LQQI RDTL EVSE FFRR HEVI GSSL LFVH DHCH RAGV WLID FGKT TPLP DGQI LDHR RPWE EGNR EDGY LLGL DNLI GILA SLAE R
Gene ID:3706
Uniprot:P23677
Cellular Location:
Calculated MW:51kDa
Observed MW:55kDa
Anti-ITPKA Antibody (CAB17503)Western blot - ITPKA Polyclonal Antibody (CAB17503)
Synonyms:IP3-3KA, IP3KA, ITPKA
Background:Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1, 4, 5-trisphosphate to Ins(1, 3, 4, 5)P4. The activity of the inositol 1, 4, 5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]
UniProt Protein Function:ITPKA: Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]
UniProt Protein Details:

Protein type:Carbohydrate Metabolism - inositol phosphate; Kinase, lipid; EC 2.7.1.127; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: cytosol; dendritic spine

Molecular Function:ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; inositol trisphosphate 3-kinase activity; Rac GTPase binding

Biological Process: actin cytoskeleton organization and biogenesis; inositol metabolic process; inositol phosphate metabolic process; protein amino acid phosphorylation; regulation of synaptic plasticity; signal transduction

NCBI Summary:Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]
UniProt Code:P23677
NCBI GenInfo Identifier:4504789
NCBI Gene ID:3706
NCBI Accession:NP_002211.1
UniProt Secondary Accession:P23677,Q8TAN3,
UniProt Related Accession:P23677
Molecular Weight:51kDa
NCBI Full Name:inositol-trisphosphate 3-kinase A
NCBI Synonym Full Names:inositol-trisphosphate 3-kinase A
NCBI Official Symbol:ITPKA  
NCBI Official Synonym Symbols:IP3KA; IP3-3KA  
NCBI Protein Information:inositol-trisphosphate 3-kinase A
UniProt Protein Name:Inositol-trisphosphate 3-kinase A
UniProt Synonym Protein Names:Inositol 1,4,5-trisphosphate 3-kinase A; IP3 3-kinase A; IP3K A; InsP 3-kinase A
Protein Family:Inositol-trisphosphate 3-kinase
UniProt Gene Name:ITPKA  
UniProt Entry Name:IP3KA_HUMAN
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