Cell Biology Antibodies 6
Anti-ITGA1 Antibody (CAB16054)
- SKU:
- CAB16054
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ITGA1 Antibody |
| Antibody SKU: | CAB16054 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human ITGA1 (NP_852478.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse kidney, Rat lung |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human ITGA1 (NP_852478.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ATVC FDVK LKSK EDTI YEAD LQYR VTLD SLRQ ISRS FFSG TQER KVQR NITV RKSE CTKH SFYM LDKH DFQD SVRI TLDF NLTD PENG PVLD DSLP NSVH E |
| Gene ID: | 3672 |
| Uniprot: | P56199 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 130kDa |
| Observed MW: | 200kDa |
| Synonyms: | ITGA1, CD49a, VLA1 |
| Background: | This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. |
| UniProt Protein Function: | ITGA1: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Belongs to the integrin alpha chain family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 5q11.2 Cellular Component: neuron projection; focal adhesion; cell surface; membrane; plasma membrane; acrosome; perikaryon; integrin complex; lipid raft; external side of plasma membrane Molecular Function:collagen binding; protein binding; metal ion binding; protein phosphatase binding; receptor binding Biological Process: positive regulation of phosphoprotein phosphatase activity; integrin-mediated signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; axon guidance; neutrophil chemotaxis; extracellular matrix organization and biogenesis; activation of MAPK activity; cell-matrix adhesion; vasodilation; negative regulation of cell proliferation; muscle contraction; cellular extravasation; positive regulation of neuron apoptosis; blood coagulation |
| NCBI Summary: | This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P56199 |
| NCBI GenInfo Identifier: | 124056463 |
| NCBI Gene ID: | 3672 |
| NCBI Accession: | P56199.2 |
| UniProt Secondary Accession: | P56199,B2RNU0, |
| UniProt Related Accession: | P56199 |
| Molecular Weight: | 130,848 Da |
| NCBI Full Name: | Integrin alpha-1 |
| NCBI Synonym Full Names: | integrin, alpha 1 |
| NCBI Official Symbol: | ITGA1 |
| NCBI Official Synonym Symbols: | VLA1; CD49a |
| NCBI Protein Information: | integrin alpha-1; VLA-1; laminin and collagen receptor; very late activation protein 1; CD49 antigen-like family member A |
| UniProt Protein Name: | Integrin alpha-1 |
| UniProt Synonym Protein Names: | CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1; CD_antigen: CD49a |
| Protein Family: | Integrin |
| UniProt Gene Name: | ITGA1 |
| UniProt Entry Name: | ITA1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ITGA1 antibody (CAB16054) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min. |
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