Antibody Name:	Anti-ISL1 Antibody
Antibody SKU:	CAB5245
Antibody Size:	20uL, 50uL, 100uL
Application:	IF
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of human ISL1 (NP_002193.2).

Application:	IF
Recommended Dilution:	IF 1:50 - 1:200
Reactivity:	Human
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of human ISL1 (NP_002193.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MGDM GDPP KKKR LISL CVGC GNQI HDQY ILRV SPDL EWHA ACLK CAEC NQYL DESC TCFV RDGK TYCK RDYI RLYG IKCA KCSI GFSK NDFV MRAR SKVY HIEC FRCV ACSR QLIP GDEF ALRE DGLF CRAD HDVV ERAS LGAG DPLS PLHP ARPL QMAA EPIS ARQP ALRP HVHK QPEK TTRV RTVL NEKQ LHTL RTCY AANP RPDA LMKE QLVE MTGL SPRV IRVW FQNK RCKD KKRS IMMK QLQQ QQPN DKTN IQGM TGTP MVAA SPER HDGG LQAN PVEV QSYQ PPWK VLSD FALQ SDID QPAF QQLV NFSE GGPG SNST GSEV ASMS SQLP DTPN SMVA SPIE A
Gene ID:	3670
Uniprot:	P61371
Cellular Location:	Nucleus
Calculated MW:	39kDa
Observed MW:

Synonyms:

ISL1, ISLET1, Isl-1

Background:

This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.

UniProt Protein Function:	ISL1: Binds to one of the cis-acting domain of the insulin gene enhancer.
UniProt Protein Details:	Protein type:Cell development/differentiation; Nuclear receptor co-regulator; DNA-binding; Transcription factor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 5q11.1 Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus Molecular Function:ligand-dependent nuclear receptor binding; zinc ion binding; bHLH transcription factor binding; estrogen receptor binding; chromatin binding Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of interleukin-12 production; positive regulation of interleukin-1 alpha production; negative regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of estrogen receptor signaling pathway; pancreas development; positive regulation of cell proliferation; ventricular cardiac muscle morphogenesis; neuron fate specification; negative regulation of neuron apoptosis; sensory system development; neural crest cell migration; positive regulation of DNA binding; trigeminal nerve development; pharyngeal system development; axon regeneration; spinal cord motor neuron cell fate specification; positive regulation of insulin secretion; positive regulation of interleukin-6 production; spinal cord motor neuron differentiation; positive regulation of tumor necrosis factor production; positive regulation of interleukin-1 beta production; positive regulation of interferon-gamma production; negative regulation of neuron differentiation; positive regulation of angiogenesis; mesenchymal cell differentiation; visceral motor neuron differentiation; pituitary gland development; negative regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; peripheral nervous system neuron axonogenesis; retinal ganglion cell axon guidance
NCBI Summary:	This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]
UniProt Code:	P61371
NCBI GenInfo Identifier:	47606423
NCBI Gene ID:	3670
NCBI Accession:	P61371.1
UniProt Secondary Accession:	P61371,P20663, P47894,
UniProt Related Accession:	P61371
Molecular Weight:	349
NCBI Full Name:	Insulin gene enhancer protein ISL-1
NCBI Synonym Full Names:	ISL LIM homeobox 1
NCBI Official Symbol:	ISL1
NCBI Official Synonym Symbols:	Isl-1; ISLET1
NCBI Protein Information:	insulin gene enhancer protein ISL-1; islet-1; ISL1 transcription factor, LIM/homeodomain
UniProt Protein Name:	Insulin gene enhancer protein ISL-1
Protein Family:	Insulin gene enhancer protein
UniProt Gene Name:	ISL1
UniProt Entry Name:	ISL1_HUMAN