Epigenetics & Nuclear Signaling Antibodies 5

Anti-IRF2 Antibody (CAB4843)

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SKU:
CAB4843
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
IRF-2
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:IRF2 Rabbit mAb
Product Code:CAB4843
Size:20uL, 50uL, 100uL
Synonyms:IRF-2
Applications:WB, IP
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human IRF2
Applications:WB, IP
Recommended Dilutions:WB 1:500 - 1:2000 IP 1:50 - 1:200
Reactivity:Human
Positive Samples:HeLa
Immunogen:A synthesized peptide derived from human IRF2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3660
Uniprot:P14316
Cellular Location:Nucleus
Calculated MW:50kDa
Observed MW:50KDa
UniProt Protein Function:IRF2: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity. By viruses and IFN. Expressed throughout the epithelium of the colon. Also expressed in lamina propria. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 4q34.1-q35.1

Cellular Component: nucleoplasm; focal adhesion; cytoplasm; cytosol

Molecular Function:protein binding; DNA binding; transcription factor activity

Biological Process: cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; blood coagulation

NCBI Summary:IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]
UniProt Code:P14316
NCBI GenInfo Identifier:20141499
NCBI Gene ID:3660
NCBI Accession:P14316.2
UniProt Secondary Accession:P14316,Q6IAS7, Q96B99, D6RCK5, H0Y8S3,
UniProt Related Accession:P14316
Molecular Weight:39,156 Da
NCBI Full Name:Interferon regulatory factor 2
NCBI Synonym Full Names:interferon regulatory factor 2
NCBI Official Symbol:IRF2  
NCBI Official Synonym Symbols:IRF-2  
NCBI Protein Information:interferon regulatory factor 2
UniProt Protein Name:Interferon regulatory factor 2
Protein Family:Interferon regulatory factor
UniProt Gene Name:IRF2  
UniProt Entry Name:IRF2_HUMAN
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