Immunology Antibodies 2
Anti-IRAK3 Antibody (CAB5467)
- SKU:
- CAB5467
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-IRAK3 Antibody |
| Antibody SKU: | CAB5467 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 367-596 of human IRAK3 (NP_009130.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | THP-1, NCI-H125, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 367-596 of human IRAK3 (NP_009130.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VLTG CRVV LDDP KHIQ LRDL LREL MEKR GLDS CLSF LDKK VPPC PRNF SAKL FCLA GRCA ATRA KLRP SMDE VLNT LEST QASL YFAE DPPT SLKS FRCP SPLF LENV PSIP VEDD ESQN NNLL PSDE GLRI DRMT QKTP FECS QSEV MFLS LDKK PESK RNEE ACNM PSSS CEES WFPK YIVP SQDL RPYK VNID PSSE APGH SCRS RPVE SSCS SKFS WDEY EQYK KE |
| Gene ID: | 11213 |
| Uniprot: | Q9Y616 |
| Cellular Location: | |
| Calculated MW: | 60kDa/67kDa |
| Observed MW: | 68kDa |
| Synonyms: | IRAK3, ASRT5, IRAKM |
| Background: | This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | IRAK3: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs. |
| UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.1; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; IRAK family Chromosomal Location of Human Ortholog: 12q14.3 Cellular Component: interleukin-1 receptor complex; cytoplasm; nucleus Molecular Function:protein serine/threonine kinase activity; protein homodimerization activity; protein heterodimerization activity; magnesium ion binding; ATP binding Biological Process: negative regulation of MAP kinase activity; negative regulation of interleukin-12 production; regulation of protein complex disassembly; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; response to virus; response to lipopolysaccharide; negative regulation of tumor necrosis factor production; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; MyD88-dependent toll-like receptor signaling pathway; response to exogenous dsRNA; negative regulation of innate immune response; inhibition of NF-kappaB transcription factor; response to peptidoglycan; negative regulation of toll-like receptor signaling pathway; negative regulation of interleukin-6 production; toll-like receptor signaling pathway; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of protein catabolic process; negative regulation of protein complex disassembly Disease: Asthma-related Traits, Susceptibility To, 5 |
| NCBI Summary: | This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
| UniProt Code: | Q9Y616 |
| NCBI GenInfo Identifier: | 322510038 |
| NCBI Gene ID: | 11213 |
| NCBI Accession: | Q9Y616.2 |
| UniProt Secondary Accession: | Q9Y616,B4DQ57, |
| UniProt Related Accession: | Q9Y616 |
| Molecular Weight: | 596 |
| NCBI Full Name: | Interleukin-1 receptor-associated kinase 3 |
| NCBI Synonym Full Names: | interleukin-1 receptor-associated kinase 3 |
| NCBI Official Symbol: | IRAK3 |
| NCBI Official Synonym Symbols: | ASRT5; IRAKM |
| NCBI Protein Information: | interleukin-1 receptor-associated kinase 3; IRAK3; IL-1 receptor-associated kinase M |
| UniProt Protein Name: | Interleukin-1 receptor-associated kinase 3 |
| UniProt Synonym Protein Names: | IL-1 receptor-associated kinase M; IRAK-M |
| Protein Family: | Interleukin-1 receptor-associated kinase |
| UniProt Gene Name: | IRAK3 |
| UniProt Entry Name: | IRAK3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IRAK3 antibody (CAB5467) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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