Anti-IQGAP1 Antibody (CAB9765)
- SKU:
- CAB9765
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HUMORFA01
- Synonyms:
- SAR1
- Synonyms:
- p195
- Research Area:
- Immunology
Description
| Product Name: | IQGAP1 Rabbit mAb |
| Product Code: | CAB9765 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | HUMORFA01, SAR1, p195 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human IQGAP1 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG, Mouse lung |
| Immunogen: | A synthesized peptide derived from human IQGAP1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8826 |
| Uniprot: | P46940 |
| Calculated MW: | 195kDa |
| Observed MW: | 195kDa |
| UniProt Protein Function: | IQGAP1: Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6. Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; GAPs, Ras; GAPs Chromosomal Location of Human Ortholog: 15q26.1 Cellular Component: actin cytoskeleton; actin filament; axon; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; growth cone; microtubule; microtubule cytoskeleton; midbody; neuron projection; plasma membrane; ruffle Molecular Function:calcium ion binding; calmodulin binding; GTPase inhibitor activity; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase binding; protein serine/threonine kinase activator activity Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of protein kinase activity; signal transduction |
| NCBI Summary: | This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P46940 |
| NCBI GenInfo Identifier: | 1170586 |
| NCBI Gene ID: | 8826 |
| NCBI Accession: | P46940.1 |
| UniProt Secondary Accession: | P46940,A7MBM3, |
| UniProt Related Accession: | P46940 |
| Molecular Weight: | 189,252 Da |
| NCBI Full Name: | Ras GTPase-activating-like protein IQGAP1 |
| NCBI Synonym Full Names: | IQ motif containing GTPase activating protein 1 |
| NCBI Official Symbol: | IQGAP1 |
| NCBI Official Synonym Symbols: | SAR1; p195; HUMORFA01 |
| NCBI Protein Information: | ras GTPase-activating-like protein IQGAP1 |
| UniProt Protein Name: | Ras GTPase-activating-like protein IQGAP1 |
| UniProt Synonym Protein Names: | p195 |
| Protein Family: | Ras GTPase-activating-like protein |
| UniProt Gene Name: | IQGAP1 |
| UniProt Entry Name: | IQGA1_HUMAN |
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