Cell Biology Antibodies 18

Anti-IPO7 Antibody (CAB18417)

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SKU:
CAB18417
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-IPO7 Antibody
Antibody SKU:CAB18417
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human IPO7.
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-251MG, HepG2, HeLa, Mouse heart, Mouse brain, Rat brain
Immunogen:A synthetic peptide of human IPO7.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10527
Uniprot:O95373
Cellular Location:
Calculated MW:
Observed MW:130kDa
Anti-IPO7 Antibody (CAB18417)Western blot - IPO7 Rabbit pAb (CAB18417)
Synonyms:Imp7, RANBP7, IPO7
Background:
UniProt Protein Function:IPO7: a beta importin protein. Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin beta-1 subunit. A receptor for nuclear localization signals (NLS) that promotes translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.
UniProt Protein Details:

Protein type:Nuclear import; Karyopherin; Nuclear export

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: nucleoplasm; membrane; cytoplasm; nuclear pore

Molecular Function:protein binding; histone binding; transporter activity; Ran GTPase binding

Biological Process: viral reproduction; protein import into nucleus; regulation of catalytic activity; innate immune response; signal transduction

NCBI Summary:The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]
UniProt Code:O95373
NCBI GenInfo Identifier:5453998
NCBI Gene ID:10527
NCBI Accession:NP_006382.1
UniProt Secondary Accession:O95373,Q1RMF7, Q9H177, Q9NTE3, A6NNM5, B2R786,
UniProt Related Accession:O95373
Molecular Weight:119517
NCBI Full Name:importin-7
NCBI Synonym Full Names:importin 7
NCBI Official Symbol:IPO7  
NCBI Official Synonym Symbols:Imp7; RANBP7  
NCBI Protein Information:importin-7
UniProt Protein Name:Importin-7
UniProt Synonym Protein Names:Ran-binding protein 7; RanBP7
Protein Family:Importin
UniProt Gene Name:IPO7  
UniProt Entry Name:IPO7_HUMAN
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