Anti-INTS6 Antibody (CAB20602)
- SKU:
- CAB20602
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- INTS6
- Synonyms:
- DBI-1
- Synonyms:
- DDX26
- Synonyms:
- DDX26A
- Synonyms:
- DICE1
- Synonyms:
- HDB
- Synonyms:
- INT6
- Synonyms:
- Notchl2
- Research Area:
- Cell Biology
Description
| Product Name: | INTS6 Rabbit pAb |
| Product Code: | CAB20602 |
| Size: | 50uL, 100uL |
| Synonyms: | INTS6, DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human INTS6. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, Mouse testis, Rat testis |
| Immunogen: | Recombinant protein of human INTS6. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 26512 |
| Uniprot: | Q9UL03 |
| Cellular Location: | Nucleus |
| Calculated MW: | 12kDa/98kDa/100kDa |
| Observed MW: | 117KDa |
| UniProt Protein Function: | INTS6: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth. Belongs to the Integrator subunit 6 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA processing; Receptor, misc. Chromosomal Location of Human Ortholog: 13q14.3 Cellular Component: nucleoplasm; integrator complex; actin cytoskeleton Molecular Function:protein binding; transmembrane receptor activity Biological Process: snRNA processing; signal transduction |
| NCBI Summary: | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UL03 |
| NCBI GenInfo Identifier: | 74753376 |
| NCBI Gene ID: | 26512 |
| NCBI Accession: | Q9UL03.1 |
| UniProt Secondary Accession: | Q9UL03,Q0P664, Q6PJP4, Q9UFK0, Q9Y5M9, |
| UniProt Related Accession: | Q9UL03 |
| Molecular Weight: | 887 |
| NCBI Full Name: | Integrator complex subunit 6 |
| NCBI Synonym Full Names: | integrator complex subunit 6 |
| NCBI Official Symbol: | INTS6 |
| NCBI Official Synonym Symbols: | HDB; INT6; DBI-1; DDX26; DICE1; DDX26A; Notchl2 |
| NCBI Protein Information: | integrator complex subunit 6; DEAD box protein; RNA helicase HDB; protein deleted in cancer 1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 |
| UniProt Protein Name: | Integrator complex subunit 6 |
| UniProt Synonym Protein Names: | DBI-1; Protein DDX26; Protein deleted in cancer 1; DICE1 |
| Protein Family: | Integrator complex |
| UniProt Gene Name: | INTS6 |
| UniProt Entry Name: | INT6_HUMAN |
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