Cell Biology Antibodies 10
Anti-INPP5J Antibody (CAB6631)
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- SKU:
- CAB6631
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-INPP5J Antibody |
| Antibody SKU: | CAB6631 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-360 of human INPP5J (NP_001002837.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, A375 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-360 of human INPP5J (NP_001002837.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VTWN VGTA MPPD DVTS LLHL GGGD DSDG ADMI AIGL QEVN SMLN KRLK DALF TDQW SELF MDAL GPFN FVLV SSVR MQGV ILLL FAKY YHLP FLRD VQTD CTRT GLGG YWGN KGGV SVRL AAFG HMLC FLNC HLPA HMDK AEQR KDNF QTIL SLQQ FQGP GAQG ILDH DLVF WFGD LNFR IESY DLHF VKFA IDSD QLHQ LWEK DQLN MAKN TWPI LKGF QEGP LNFA PTFK FDVG TNKY DTSA KKRK PAWT DRIL WKVK APGG GPSP SGRK SHRL QVTQ HSYR SHME YTVS DHKP VAAQ F |
| Gene ID: | 27124 |
| Uniprot: | Q15735 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 70kDa/107kDa |
| Observed MW: | 107kDa |
| Synonyms: | INPP5J, INPP5, PIB5PA, PIPP |
| Background: |
| UniProt Protein Function: | PI5PA: Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate- binding proteins that are present at membranes ruffles. Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.56; Phosphatase (non-protein) Chromosomal Location of Human Ortholog: 22q12.2 Cellular Component: ruffle; growth cone; cytoplasm; plasma membrane; dendritic shaft; cytosol Molecular Function:inositol-polyphosphate 5-phosphatase activity; SH3 domain binding Biological Process: inositol phosphate metabolic process; negative regulation of microtubule polymerization; phospholipid metabolic process; phosphatidylinositol biosynthetic process; negative regulation of peptidyl-serine phosphorylation; phosphoinositide dephosphorylation |
| UniProt Code: | Q15735 |
| NCBI GenInfo Identifier: | 116242713 |
| NCBI Gene ID: | 27124 |
| NCBI Accession: | Q15735.3 |
| UniProt Secondary Accession: | Q15735,Q32M61, Q6ZTH6, Q8N902, Q9UDT9, B3KS54, |
| UniProt Related Accession: | Q15735 |
| Molecular Weight: | 1006 |
| NCBI Full Name: | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A |
| NCBI Synonym Full Names: | inositol polyphosphate-5-phosphatase J |
| NCBI Official Symbol: | INPP5J |
| NCBI Official Synonym Symbols: | PIPP; INPP5; PIB5PA |
| NCBI Protein Information: | phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; inositol polyphosphate 5-phosphatase J; phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A |
| UniProt Protein Name: | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A |
| UniProt Synonym Protein Names: | Inositol polyphosphate 5-phosphatase J |
| Protein Family: | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase |
| UniProt Gene Name: | INPP5J |
| UniProt Entry Name: | PI5PA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using INPP5J antibody (CAB6631) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat liver using INPP5J Antibody (CAB6631) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat kidney using INPP5J Antibody (CAB6631) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using INPP5J Antibody (CAB6631) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using INPP5J antibody (CAB6631). Blue: DAPI for nuclear staining. |
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