Developmental Biology
Anti-INA Antibody (CAB3109)
- SKU:
- CAB3109
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-INA Antibody |
| Antibody SKU: | CAB3109 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human INA |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, Jurkat, Mouse brain, Mouse spinal cord |
| Immunogen: | A synthetic peptide of human INA |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9118 |
| Uniprot: | Q16352 |
| Cellular Location: | |
| Calculated MW: | 55kDa |
| Observed MW: | 65kDa |
| Synonyms: | INA, NEF5, NF-66, TXBP-1 |
| Background: | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. |
| UniProt Protein Function: | INA: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges. Belongs to the intermediate filament family. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 10q24.33 Cellular Component: extracellular space; intermediate filament cytoskeleton; nuclear membrane; nucleoplasm Molecular Function:structural constituent of cytoskeleton Biological Process: substantia nigra development |
| NCBI Summary: | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009] |
| UniProt Code: | Q16352 |
| NCBI GenInfo Identifier: | 20141266 |
| NCBI Gene ID: | 9118 |
| NCBI Accession: | Q16352.2 |
| UniProt Secondary Accession: | Q16352,Q9BRC5, B1AQK0, |
| UniProt Related Accession: | Q16352 |
| Molecular Weight: | 55,391 Da |
| NCBI Full Name: | Alpha-internexin |
| NCBI Synonym Full Names: | internexin neuronal intermediate filament protein alpha |
| NCBI Official Symbol: | INA |
| NCBI Official Synonym Symbols: | NEF5; NF-66; TXBP-1 |
| NCBI Protein Information: | alpha-internexin |
| UniProt Protein Name: | Alpha-internexin |
| UniProt Synonym Protein Names: | 66 kDa neurofilament protein; NF-66; Neurofilament-66; Neurofilament 5 |
| Protein Family: | Immune inhibitor |
| UniProt Gene Name: | INA |
| UniProt Entry Name: | AINX_HUMAN |
 | Western blot analysis of extracts of various cell lines, using INA antibody (CAB3109) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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