Developmental Biology

Anti-INA Antibody (CAB3109)

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SKU:
CAB3109
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-INA Antibody
Antibody SKU:CAB3109
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide of human INA
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, Jurkat, Mouse brain, Mouse spinal cord
Immunogen:A synthetic peptide of human INA
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9118
Uniprot:Q16352
Cellular Location:
Calculated MW:55kDa
Observed MW:65kDa
Synonyms:INA, NEF5, NF-66, TXBP-1
Background:Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons.
UniProt Protein Function:INA: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges. Belongs to the intermediate filament family.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 10q24.33

Cellular Component: extracellular space; intermediate filament cytoskeleton; nuclear membrane; nucleoplasm

Molecular Function:structural constituent of cytoskeleton

Biological Process: substantia nigra development

NCBI Summary:Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]
UniProt Code:Q16352
NCBI GenInfo Identifier:20141266
NCBI Gene ID:9118
NCBI Accession:Q16352.2
UniProt Secondary Accession:Q16352,Q9BRC5, B1AQK0,
UniProt Related Accession:Q16352
Molecular Weight:55,391 Da
NCBI Full Name:Alpha-internexin
NCBI Synonym Full Names:internexin neuronal intermediate filament protein alpha
NCBI Official Symbol:INA  
NCBI Official Synonym Symbols:NEF5; NF-66; TXBP-1  
NCBI Protein Information:alpha-internexin
UniProt Protein Name:Alpha-internexin
UniProt Synonym Protein Names:66 kDa neurofilament protein; NF-66; Neurofilament-66; Neurofilament 5
Protein Family:Immune inhibitor
UniProt Gene Name:INA  
UniProt Entry Name:AINX_HUMAN
Anti-INA Antibody (CAB3109)Western blot analysis of extracts of various cell lines, using INA antibody (CAB3109) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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