Epigenetics & Nuclear Signaling Antibodies 5

Anti-IMP2 Antibody (CAB5189)

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SKU:
CAB5189

Description

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Antibody Name:Anti-IMP2 Antibody
Antibody SKU:CAB5189
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human IMP2
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:HT-29, 293T, HepG2
Immunogen:A synthesized peptide derived from human IMP2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10644
Uniprot:Q9Y6M1
Cellular Location:
Calculated MW:66, 62kDa
Observed MW:65KDa/70KDa
Synonyms:IMP-2, IMP2, VICKZ2
Background:This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]
UniProt Protein Function:IGF2BP2: Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May regulate translation of target mRNAs. Belongs to the RRM IMP/VICKZ family. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA-binding; Translation

Chromosomal Location of Human Ortholog: 3q27.2

Cellular Component: cytoskeleton; cytoplasm; nucleus; cytosol

Molecular Function:protein binding; mRNA 3'-UTR binding; nucleotide binding; translation regulator activity; mRNA 5'-UTR binding

Biological Process: anatomical structure morphogenesis; mRNA transport; negative regulation of translation; gene expression; regulation of cytokine biosynthetic process

Disease: Diabetes Mellitus, Noninsulin-dependent

NCBI Summary:This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. [provided by RefSeq, May 2014]
UniProt Code:Q9Y6M1
NCBI GenInfo Identifier:224471831
NCBI Gene ID:10644
NCBI Accession:Q9Y6M1.2
UniProt Secondary Accession:Q9Y6M1,A0A4Z0, B3FTN2, B3FTN3, B3FTN4,
UniProt Related Accession:Q9Y6M1
Molecular Weight:599
NCBI Full Name:Insulin-like growth factor 2 mRNA-binding protein 2
NCBI Synonym Full Names:insulin-like growth factor 2 mRNA binding protein 2
NCBI Official Symbol:IGF2BP2  
NCBI Official Synonym Symbols:IMP2; IMP-2; VICKZ2  
NCBI Protein Information:insulin-like growth factor 2 mRNA-binding protein 2; VICKZ family member 2; IGF2 mRNA-binding protein 2; IGF-II mRNA-binding protein 2
UniProt Protein Name:Insulin-like growth factor 2 mRNA-binding protein 2
UniProt Synonym Protein Names:Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; VICKZ family member 2
Protein Family:Insulin-like growth factor 2 mRNA-binding protein
UniProt Gene Name:IGF2BP2  
UniProt Entry Name:IF2B2_HUMAN
Anti-IMP2 Antibody (CAB5189)Western blot - IMP2 Rabbit mAb (CAB5189)
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Additional Information

Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
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