Cell Biology Antibodies 11
Anti-IL-21 Antibody (CAB7235)
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- SKU:
- CAB7235
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | IL21 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB7235 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-162 of human IL21 (NP_068575.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse testis, Mouse liver, Mouse skin, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-162 of human IL21 (NP_068575.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HKSS SQGQ DRHM IRMR QLID IVDQ LKNY VNDL VPEF LPAP EDVE TNCE WSAF SCFQ KAQL KSAN TGNN ERII NVSI KKLK RKPP STNA GRRQ KHRL TCPS CDSY EKKP PKEF LERF KSLL QKMI HQHL SSRT HGSE DS |
| Gene ID: | 59067 |
| Uniprot: | Q9HBE4 |
| Cellular Location: | Secreted |
| Calculated MW: | 16kDa/17kDa |
| Observed MW: | 18kDa |
| Synonyms: | IL21, CVID11, IL-21, Za11 |
| Background: | This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | IL21: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine; Apoptosis; Secreted, signal peptide; Secreted; Cell development/differentiation Chromosomal Location of Human Ortholog: 4q26-q27 Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interleukin-2 receptor binding Biological Process: cell maturation; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of cytokine production; positive regulation of inflammatory response; positive regulation of interleukin-17 production; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tyrosine phosphorylation of Stat3 protein; tyrosine phosphorylation of Stat3 protein Disease: Immunodeficiency, Common Variable, 11 |
| NCBI Summary: | This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9HBE4 |
| NCBI GenInfo Identifier: | 55976599 |
| NCBI Gene ID: | 59067 |
| NCBI Accession: | Q9HBE4.2 |
| UniProt Secondary Accession: | Q9HBE4,A5J0L4, |
| UniProt Related Accession: | Q9HBE4 |
| Molecular Weight: | 16,867 Da |
| NCBI Full Name: | Interleukin-21 |
| NCBI Synonym Full Names: | interleukin 21 |
| NCBI Official Symbol: | IL21 |
| NCBI Official Synonym Symbols: | Za11; IL-21; CVID11 |
| NCBI Protein Information: | interleukin-21 |
| UniProt Protein Name: | Interleukin-21 |
| UniProt Synonym Protein Names: | Za11 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL21 |
| UniProt Entry Name: | IL21_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL21 antibody (CAB7235) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat spleen using IL21 antibody (CAB7235) at dilution of 1:100 (40x lens). |
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